Human Gene GPR98 (uc003kjt.4) Description and Page Index
  Description: Homo sapiens G protein-coupled receptor 98 (GPR98), transcript variant 2, non-coding RNA.
RefSeq Summary (NR_003149): This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr5:89,854,617-90,460,033 Size: 605,417 Total Exon Count: 90 Strand: +


Page IndexSequence and LinksGenetic AssociationsCTDRNA-Seq ExpressionMicroarray Expression
Other SpeciesmRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:89,854,617-90,460,033)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerH-INV
HGNCHuman Cortex Gene ExpressionLynxOMIMPubMedStanford SOURCE
Wikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): GPR98
CDC HuGE Published Literature: GPR98
Positive Disease Associations: Benzodiazepines , Body Weight , Bone Density , Calcium , Carotid Artery Diseases , Carotid Stenosis , Coronary Artery Disease , Hip , hip geometry , response to antipsychotic treatment
Related Studies:
  1. Benzodiazepines
    D E Adkins et al. Molecular psychiatry 2011, Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs., Molecular psychiatry. [PubMed 20195266]
  2. Body Weight
    Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics. [PubMed 17903300]
    Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
  3. Bone Density
    Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics. [PubMed 17903296]
    The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.00 RPKM in Adrenal Gland
Total median expression: 80.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AF435925 - Homo sapiens very large G protein-coupled receptor 1b (VLGR1) mRNA, complete cds.
AF055084 - Homo sapiens very large G-protein coupled receptor-1 (VLGR1) mRNA, complete cds.
AK024416 - Homo sapiens cDNA FLJ14354 fis, clone Y79AA1001384, highly similar to Monogenic audiogenic seizure susceptibility protein 1 homolog precursor.
AB014586 - Homo sapiens mRNA for KIAA0686 protein, partial cds.
BC172212 - Synthetic construct Homo sapiens clone IMAGE:9094358 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC172199 - Synthetic construct Homo sapiens clone IMAGE:9094289 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC172219 - Synthetic construct Homo sapiens clone IMAGE:9094300 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
AL136541 - Homo sapiens mRNA; cDNA DKFZp761P0710 (from clone DKFZp761P0710).
BC172210 - Synthetic construct Homo sapiens clone IMAGE:9094354 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
BC034748 - Homo sapiens G protein-coupled receptor 98, mRNA (cDNA clone IMAGE:5183306), with apparent retained intron.
JD206042 - Sequence 187066 from Patent EP1572962.
BC172200 - Synthetic construct Homo sapiens clone IMAGE:9094290 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
AB075823 - Homo sapiens mRNA for KIAA1943 protein.
AL133041 - Homo sapiens mRNA; cDNA DKFZp434L2050 (from clone DKFZp434L2050).
BC172211 - Synthetic construct Homo sapiens clone IMAGE:9094356 G protein-coupled receptor 98 precursor (GPR98) gene, partial cds.
JD288327 - Sequence 269351 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NR_003149, uc003kjt.3
UCSC ID: uc003kjt.4
RefSeq Accession: NR_003149

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: yes RNA accession: NR_003149.1
exon count: 90CDS single in 3' UTR: no RNA size: 19250
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 13341.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.