Human Gene SUPT3H (uc003oxp.4) Description and Page Index
  Description: Homo sapiens suppressor of Ty 3 homolog (S. cerevisiae) (SUPT3H), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr6:44,794,467-45,345,788 Size: 551,322 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr6:44,797,553-45,333,038 Size: 535,486 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:44,794,467-45,345,788)mRNA (may differ from genome)Protein (317 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
neXtProtOMIMPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transcription initiation protein SPT3 homolog; AltName: Full=SPT3-like protein;
FUNCTION: Probable transcriptional activator.
SUBUNIT: Component of the PCAF complex, at least composed of TADA2L/ADA2, SUPT3H, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65- alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Associates with TAFII31 and GCN5L2. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.
TISSUE SPECIFICITY: Expressed in all tissues tested including pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SUPT3H
CDC HuGE Published Literature: SUPT3H
Positive Disease Associations: ADHD | attention-deficit hyperactivity disorder , Albumins , Attention Deficit Disorder with Hyperactivity , Body Height , height , Insulin , Occipital Lobe , smoking cessation
Related Studies:
  1. ADHD | attention-deficit hyperactivity disorder
    Lesch ,et al. 2008, Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies, Journal of neural transmission (Vienna, Austria : 1996) 2008 115- 11 : 1573-85. [PubMed 18839057]
  2. Albumins
    , , . [PubMed 0]
  3. Attention Deficit Disorder with Hyperactivity
    Klaus-Peter Lesch et al. Journal of neural transmission (Vienna, Austria : 1996) 2008, Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies., Journal of neural transmission (Vienna, Austria : 1996). [PubMed 18839057]
           more ... click here to view the complete list

-  MalaCards Disease Associations
  MalaCards Gene Search: SUPT3H
Diseases sorted by gene-association score: blastic plasmacytoid dendritic cell (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.02 RPKM in Testis
Total median expression: 107.61 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -69.81284-0.246 Picture PostScript Text
3' UTR -696.523086-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009072 - Histone-fold
IPR003195 - TFIID-18

Pfam Domains:
PF02269 - Transcription initiation factor IID, 18kD subunit

SCOP Domains:
47113 - Histone-fold

ModBase Predicted Comparative 3D Structure on O75486
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserGenome BrowserNo orthologGenome Browser
Gene Details  Gene Details Gene Details
Gene Sorter  Gene Sorter Gene Sorter
  EnsemblFlyBase SGD
  Protein SequenceProtein Sequence Protein Sequence
  AlignmentAlignment Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0046982 protein heterodimerization activity
GO:0004402 histone acetyltransferase activity

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0016578 histone deubiquitination
GO:0043966 histone H3 acetylation
GO:0045893 positive regulation of transcription, DNA-templated

Cellular Component:
GO:0000124 SAGA complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0030914 STAGA complex
GO:0033276 transcription factor TFTC complex
GO:0005669 transcription factor TFIID complex

-  Descriptions from all associated GenBank mRNAs
  AF064804 - Homo sapiens transcription factor SUPT3H (SUPT3H) mRNA, complete cds.
BC050384 - Homo sapiens suppressor of Ty 3 homolog (S. cerevisiae), mRNA (cDNA clone MGC:51927 IMAGE:5758833), complete cds.
BC035816 - Homo sapiens suppressor of Ty 3 homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5768301), partial cds.
AK303838 - Homo sapiens cDNA FLJ50351 complete cds, highly similar to Transcription initiation protein SPT3 homolog.
AF073930 - Homo sapiens histone acetylase complex subunit (SPT3) mRNA, complete cds.
AF069734 - Homo sapiens SPT3-like protein mRNA, complete cds.
AK313874 - Homo sapiens cDNA, FLJ94507, highly similar to Homo sapiens suppressor of Ty 3 homolog (S. cerevisiae) (SUPT3H), transcript variant 1, mRNA.
KJ904599 - Synthetic construct Homo sapiens clone ccsbBroadEn_13993 SUPT3H-like gene, encodes complete protein.
EU446927 - Synthetic construct Homo sapiens clone IMAGE:100070335; IMAGE:100012136; FLH257233.01L suppressor of Ty 3 homolog (S. cerevisiae) (SUPT3H) gene, encodes complete protein.
AB527737 - Synthetic construct DNA, clone: pF1KB7904, Homo sapiens SUPT3H gene for suppressor of Ty 3 homolog, without stop codon, in Flexi system.
CU690660 - Synthetic construct Homo sapiens gateway clone IMAGE:100021384 5' read SUPT3H mRNA.
AF279781 - Homo sapiens clone N12 NTera2D1 teratocarcinoma mRNA.
LF213811 - JP 2014500723-A/21314: Polycomb-Associated Non-Coding RNAs.
MA449388 - JP 2018138019-A/21314: Polycomb-Associated Non-Coding RNAs.
AK092340 - Homo sapiens cDNA FLJ35021 fis, clone OCBBF2014880.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75486 (Reactome details) participates in the following event(s):

R-HSA-3301237 KAT2 complexes acetylate histone H3
R-HSA-3214847 HATs acetylate histones
R-HSA-3247509 Chromatin modifying enzymes
R-HSA-4839726 Chromatin organization

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKG9, B2R9Q5, NM_003599, NP_001248752, O75486, O76066, Q5TAV9, Q86VN7, SPT3, SUPT3_HUMAN, uc003oxp.3
UCSC ID: uc003oxp.4
RefSeq Accession: NM_003599
Protein: O75486 (aka SUPT3_HUMAN or SUT3_HUMAN)
CCDS: CCDS34465.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_003599.3
exon count: 11CDS single in 3' UTR: no RNA size: 4324
ORF size: 954CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1966.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 3034# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.