Human Gene MYB (ENST00000442647.7)
  Description: Homo sapiens MYB proto-oncogene, transcription factor (MYB), transcript variant 14, non-coding RNA. (from RefSeq NR_134963)
RefSeq Summary (NM_001130172): This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000442647.7
Gencode Gene: ENSG00000118513.19
Transcript (Including UTRs)
   Position: hg38 chr6:135,181,308-135,219,172 Size: 37,865 Total Exon Count: 15 Strand: +
Coding Region
   Position: hg38 chr6:135,181,514-135,217,980 Size: 36,467 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2021-01-14 15:32:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:135,181,308-135,219,172)mRNA (may differ from genome)Protein (637 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGImyGene2neXtProtOMIMPubMed
ReactomeUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MYB_HUMAN
DESCRIPTION: RecName: Full=Transcriptional activator Myb; AltName: Full=Proto-oncogene c-Myb;
FUNCTION: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
SUBUNIT: Binds MYBBP1A. Interacts with HIPK2, MAF and NLK (By similarity). Binds to HIPK1.
INTERACTION: O15083:ERC2; NbExp=2; IntAct=EBI-298355, EBI-2684336; P63165:SUMO1; NbExp=3; IntAct=EBI-298355, EBI-80140; P61956:SUMO2; NbExp=3; IntAct=EBI-298355, EBI-473220; O60293:ZFC3H1; NbExp=2; IntAct=EBI-298355, EBI-746701;
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C- terminal domain involved in transcriptional repression.
PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable).
PTM: Phosphorylated by NLK on multiple sites, which induces proteasomal degradation (By similarity).
PTM: Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
SIMILARITY: Contains 3 HTH myb-type DNA-binding domains.

-  MalaCards Disease Associations
  MalaCards Gene Search: MYB
Diseases sorted by gene-association score: angiocentric glioma* (260), acute basophilic leukemia* (247), precursor t-cell acute lymphoblastic leukemia* (106), leukemia, acute lymphoblastic* (30), tuberculous salpingitis (15), malignant histiocytosis (12), trachea adenoid cystic carcinoma (10), gallbladder adenocarcinoma (10), tracheal cancer (7), bone ewing's sarcoma (6), myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency (5), polymorphous low-grade adenocarcinoma (5), leukemia, chronic myeloid, somatic (2), leukemia, acute myeloid (0)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.02 RPKM in Colon - Transverse
Total median expression: 34.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -93.80206-0.455 Picture PostScript Text
3' UTR -276.201192-0.232 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015395 - C-myb_C
IPR009057 - Homeodomain-like
IPR017930 - Myb_dom
IPR001005 - SANT/Myb
IPR012642 - Tscrpt_reg_Wos2-domain

Pfam Domains:
PF09316 - C-myb, C-terminal
PF07988 - LMSTEN motif
PF00249 - Myb-like DNA-binding domain

ModBase Predicted Comparative 3D Structure on P10242
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting
GO:0003677 DNA binding
GO:0005515 protein binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0001666 response to hypoxia
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0032967 positive regulation of collagen biosynthetic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045624 positive regulation of T-helper cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0060252 positive regulation of glial cell proliferation
GO:0070301 cellular response to hydrogen peroxide
GO:0071300 cellular response to retinoic acid
GO:0071636 positive regulation of transforming growth factor beta production
GO:1901216 positive regulation of neuron death
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1904899 positive regulation of hepatic stellate cell proliferation
GO:2000491 positive regulation of hepatic stellate cell activation
GO:2000845 positive regulation of testosterone secretion

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016363 nuclear matrix


-  Descriptions from all associated GenBank mRNAs
  AJ606317 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8A.
AJ606318 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 9Ai.
AJ606319 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 9Aii.
AJ606320 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8.
AJ606321 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 8B.
AJ606322 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 10A.
AJ606323 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 13A.
AJ606324 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene), splice variant 14A.
FW340095 - Screening.
X52125 - Human alternatively spliced c-myb mRNA (clone=pMbm-1).
BC064955 - Homo sapiens v-myb myeloblastosis viral oncogene homolog (avian), mRNA (cDNA clone MGC:70781 IMAGE:6069320), complete cds.
AJ616235 - Homo sapiens mRNA for v-myb myeloblastosis viral oncogene homologue (avian), (c-myb gene).
M15024 - Human c-myb mRNA, complete cds.
AJ616791 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 1 and joined CDS.
JD445418 - Sequence 426442 from Patent EP1572962.
JD173383 - Sequence 154407 from Patent EP1572962.
JD057050 - Sequence 38074 from Patent EP1572962.
AF104863 - Homo sapiens MYB proto-oncogene protein (MYB) mRNA, complete cds.
AB527731 - Synthetic construct DNA, clone: pF1KB6253, Homo sapiens MYB gene for v-myb myeloblastosis viral oncogene homolog, without stop codon, in Flexi system.
KJ891658 - Synthetic construct Homo sapiens clone ccsbBroadEn_01052 MYB gene, encodes complete protein.
AY787443 - Homo sapiens isolate DelE13 c-myb-like mRNA, complete sequence.
AY787444 - Homo sapiens isolate DelE3E5 c-myb-like mRNA, complete sequence.
AY787445 - Homo sapiens isolate DelE3E8A c-myb-like mRNA, complete sequence.
AY787446 - Homo sapiens isolate DelE5E8A c-myb-like mRNA, complete sequence.
AY787447 - Homo sapiens isolate DelE8 c-myb-like mRNA, complete sequence.
AY787448 - Homo sapiens isolate DelE9 c-myb-like mRNA, complete sequence.
AY787452 - Homo sapiens isolate E12L-2 c-myb-like mRNA, complete sequence.
AY787453 - Homo sapiens isolate E13A c-myb-like mRNA, complete sequence.
AY787454 - Homo sapiens isolate E8A c-myb-like mRNA, complete sequence.
AY787455 - Homo sapiens isolate E8A2E9B c-myb-like mRNA, complete sequence.
AY787459 - Homo sapiens isolate E8SE8A c-myb-like mRNA, complete sequence.
AY787460 - Homo sapiens isolate E8SE8AE9B c-myb-like mRNA, complete sequence.
AY787461 - Homo sapiens isolate E8SE9B c-myb-like mRNA, complete sequence.
AY787462 - Homo sapiens isolate E8SE9S-85E9AB c-myb-like mRNA, complete sequence.
AY787463 - Homo sapiens isolate E8SE9S-85E9B c-myb-like mRNA, complete sequence.
AY787464 - Homo sapiens isolate E9A c-myb-like mRNA, complete sequence.
AY787465 - Homo sapiens isolate E9AB c-myb-like mRNA, complete sequence.
AY787467 - Homo sapiens isolate E9B c-myb-like mRNA, complete sequence.
AY787468 - Homo sapiens isolate E9S-48E9B c-myb-like mRNA, complete sequence.
AY787470 - Homo sapiens isolate E9S-85 c-myb-like mRNA, complete sequence.
AY787472 - Homo sapiens isolate E9S-85E9A c-myb-like mRNA, complete sequence.
AY787473 - Homo sapiens isolate E9S-85E9AB c-myb-like mRNA, complete sequence.
AY787474 - Homo sapiens isolate E9S-85E9B c-myb-like mRNA, complete sequence.
AY787475 - Homo sapiens isolate M15024 c-myb-like mRNA, complete sequence.
AY787451 - Homo sapiens isolate E12L-1 c-myb-like mRNA, complete sequence.
AY787449 - Homo sapiens isolate DelE9E10A c-myb-like mRNA, complete sequence.
AY787450 - Homo sapiens isolate E10A c-myb-like mRNA, complete sequence.
AY787456 - Homo sapiens isolate E8AE10A.txt c-myb-like mRNA, complete sequence.
AY787457 - Homo sapiens isolate E8AE9S-85E10A c-myb-like mRNA, complete sequence.
AY787458 - Homo sapiens isolate E8SE10A c-myb-like mRNA, complete sequence.
AY787466 - Homo sapiens isolate E9AE10A c-myb-like mRNA, complete sequence.
AY787469 - Homo sapiens isolate E9S-48E9BE10A c-myb-like mRNA, complete sequence.
AY787471 - Homo sapiens isolate E9S-85E10A c-myb-like mRNA, complete sequence.
X52126 - Human alternatively spliced c-myb mRNA (clone=pMbm-2).
AJ616792 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 2.
M13666 - Human c-myb mRNA, 3' end.
M13665 - Human c-myb mRNA, 3'end.
AJ616793 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 3.
AJ616794 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 4.
FJ969915 - Homo sapiens MYB/NFIB fusion protein variant 1 (MYB/NFIB fusion) mRNA, partial cds.
FJ969916 - Homo sapiens MYB/NFIB fusion protein variant 2 (MYB/NFIB fusion) mRNA, partial cds.
FJ969917 - Homo sapiens MYB/NFIB fusion protein variant 3 (MYB/NFIB fusion) mRNA, partial cds.
AJ616795 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 5.
AJ616796 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 6.
AJ616797 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 7.
BC035996 - Homo sapiens, Similar to v-myb myeloblastosis viral oncogene homolog (avian), clone IMAGE:4686589, mRNA.
AJ616798 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 8.
AJ616799 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 9.
X17469 - Human mRNA for c-myb gene exon 9A.
AJ616800 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 10.
AJ616801 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 11.
AJ616802 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 12.
CQ873766 - Sequence 185 from Patent WO2004076622.
DD413603 - Regulation of Mammalian Cells.
AJ616803 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 13.
AJ616804 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 14.
AJ616805 - Homo sapiens c-myb gene for v-myb myeloblastosis viral oncogene homologue (avian), exon 15.
JD545763 - Sequence 526787 from Patent EP1572962.
JD333991 - Sequence 315015 from Patent EP1572962.
FW573307 - JP 2010529847-A/28: Oligonucleotides for modulation of target RNA activity.
HI463868 - Sequence 13 from Patent EP2124967.
JD557793 - Sequence 538817 from Patent EP1572962.
CQ873705 - Sequence 124 from Patent WO2004076622.
DD413542 - Regulation of Mammalian Cells.
HI463869 - Sequence 14 from Patent EP2124967.
HI463870 - Sequence 15 from Patent EP2124967.
FW573305 - JP 2010529847-A/26: Oligonucleotides for modulation of target RNA activity.
FW573306 - JP 2010529847-A/27: Oligonucleotides for modulation of target RNA activity.
HI463872 - Sequence 17 from Patent EP2124967.
FW573308 - JP 2010529847-A/29: Oligonucleotides for modulation of target RNA activity.
HI463873 - Sequence 18 from Patent EP2124967.
HI463874 - Sequence 19 from Patent EP2124967.
HI463875 - Sequence 20 from Patent EP2124967.
JD232050 - Sequence 213074 from Patent EP1572962.
HI463876 - Sequence 21 from Patent EP2124967.
HI463877 - Sequence 22 from Patent EP2124967.
JD182305 - Sequence 163329 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P10242 (Reactome details) participates in the following event(s):

R-HSA-992696 p53, SIN3A and MYB form a complex
R-HSA-8956586 RUNX1-containing TAL1 complex binds the MYB gene enhancer
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-109582 Hemostasis
R-HSA-8878171 Transcriptional regulation by RUNX1
R-HSA-8939211 ESR-mediated signaling
R-HSA-212436 Generic Transcription Pathway
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-162582 Signal Transduction
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000442647.1, ENST00000442647.2, ENST00000442647.3, ENST00000442647.4, ENST00000442647.5, ENST00000442647.6, MYB_HUMAN, NR_134963, P10242, P78391, P78392, P78525, P78526, Q14023, Q14024, Q708E4, Q708E7, Q9UE83, uc003qfu.1, uc003qfu.2, uc003qfu.3, uc003qfu.4, uc003qfu.5
UCSC ID: ENST00000442647.7
RefSeq Accession: NM_001130172
Protein: P10242 (aka MYB_HUMAN)
CCDS: CCDS5174.1, CCDS47482.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.