Human Gene UFSP1 (uc003uxc.2) Description and Page Index
Description: inactive Ufm1-specific protease 1 RefSeq Summary (NM_001015072): This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]. ##Evidence-Data-START## Transcript is intronless :: SRR1163657.100801.1, SRR7346977.102642.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000388761.4/ ENSP00000373413.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Transcript (Including UTRs) Position: hg18 chr7:100,324,280-100,325,275 Size: 996 Total Exon Count: 1 Strand: - Coding Region Position: hg18 chr7:100,324,400-100,324,828 Size: 429 Coding Exon Count: 1
ID:UFSP1_HUMAN DESCRIPTION: RecName: Full=Inactive Ufm1-specific protease 1; Short=UfSP1; SIMILARITY: Belongs to the peptidase C78 family. CAUTION: Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably inactive. SEQUENCE CAUTION: Sequence=EAL23814.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07910 - Protein of unknown function (DUF1671)
ModBase Predicted Comparative 3D Structure on Q6NVU6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.