Human Gene UFSP1 (uc003uxc.2) Description and Page Index
  Description: inactive Ufm1-specific protease 1
RefSeq Summary (NM_001015072): This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]. ##Evidence-Data-START## Transcript is intronless :: SRR1163657.100801.1, SRR7346977.102642.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000388761.4/ ENSP00000373413.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg18 chr7:100,324,280-100,325,275 Size: 996 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg18 chr7:100,324,400-100,324,828 Size: 429 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:100,324,280-100,325,275)mRNA (may differ from genome)Protein (142 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
HGNCHPRDMGIOMIMPubMedStanford SOURCE
TreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: UFSP1_HUMAN
DESCRIPTION: RecName: Full=Inactive Ufm1-specific protease 1; Short=UfSP1;
SIMILARITY: Belongs to the peptidase C78 family.
CAUTION: Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably inactive.
SEQUENCE CAUTION: Sequence=EAL23814.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -226.80447-0.507 Picture PostScript Text
3' UTR -32.80120-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012462 - Peptidase_C78_UfSP1/2

Pfam Domains:
PF07910 - Protein of unknown function (DUF1671)

ModBase Predicted Comparative 3D Structure on Q6NVU6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
MGIRGD    
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0008234 cysteine-type peptidase activity
GO:0071567 UFM1 hydrolase activity

Biological Process:
GO:0006508 proteolysis
GO:0008150 biological_process


-  Descriptions from all associated GenBank mRNAs
  AK292467 - Homo sapiens cDNA FLJ76681 complete cds.
BC017456 - Homo sapiens UFM1-specific peptidase 1 (non-functional), mRNA (cDNA clone IMAGE:3919549).
BC067904 - Homo sapiens UFM1-specific peptidase 1 (non-functional), mRNA (cDNA clone MGC:87702 IMAGE:5310615), complete cds.
KJ900744 - Synthetic construct Homo sapiens clone ccsbBroadEn_10138 UFSP1 gene, encodes complete protein.
JD340035 - Sequence 321059 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A4D2E4, A8K8V2, NM_001015072, NP_001015072, Q6NVU6, Q9BXP6, uc003uxc.1, UFSP1_HUMAN
UCSC ID: uc003uxc.2
RefSeq Accession: NM_001015072
Protein: Q6NVU6 (aka UFSP1_HUMAN)
CCDS: CCDS34710.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001015072.3
exon count: 1CDS single in 3' UTR: no RNA size: 1016
ORF size: 429CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1058.00frame shift in genome: no % Coverage: 98.03
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.