Human Gene KIAA1432 (uc003zjh.2) Description and Page Index
  Description: connexin 43-interacting protein 150 isoform a
Transcript (Including UTRs)
   Position: hg18 chr9:5,619,327-5,759,452 Size: 140,126 Total Exon Count: 22 Strand: +
Coding Region
   Position: hg18 chr9:5,646,676-5,759,330 Size: 112,655 Coding Exon Count: 21 

Page IndexSequence and LinksCTDMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:5,619,327-5,759,452)mRNA (may differ from genome)Protein (1086 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCMGIOMIMPubMedReactome
Stanford SOURCETreefamUniProtKB

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -84.00220-0.382 Picture PostScript Text
3' UTR -24.20122-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF07064 - RIC1

ModBase Predicted Comparative 3D Structure on Q4ADV7-2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI Ensembl   
Protein Sequence Protein Sequence   
Alignment Alignment   

-  Descriptions from all associated GenBank mRNAs
  AL136875 - Homo sapiens mRNA; cDNA DKFZp434D105 (from clone DKFZp434D105).
LF385283 - JP 2014500723-A/192786: Polycomb-Associated Non-Coding RNAs.
LF385475 - JP 2014500723-A/192978: Polycomb-Associated Non-Coding RNAs.
MA620860 - JP 2018138019-A/192786: Polycomb-Associated Non-Coding RNAs.
MA621052 - JP 2018138019-A/192978: Polycomb-Associated Non-Coding RNAs.
BC136616 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:168229 IMAGE:9020606), complete cds.
BC144296 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:177833 IMAGE:9052816), complete cds.
AB205401 - Homo sapiens CIP150 mRNA for connexin43-interacting protein of 150 kDa, complete cds.
AK124394 - Homo sapiens cDNA FLJ42403 fis, clone ASTRO3000177, weakly similar to Drosophila melanogaster BcDNA.GH03694 (BcDNA.GH03694) mRNA.
AK022642 - Homo sapiens cDNA FLJ12580 fis, clone NT2RM4001116, weakly similar to HYPOTHETICAL 216.3 KD PROTEIN R06F6.8 IN CHROMOSOME II.
AB037853 - Homo sapiens mRNA for KIAA1432 protein, partial cds.
AB527173 - Synthetic construct DNA, clone: pF1KA1432, Homo sapiens KIAA1432 gene for KIAA1432, without stop codon, in Flexi system.
AK074150 - Homo sapiens mRNA for FLJ00223 protein.
BC030576 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4077122), partial cds.
JD468950 - Sequence 449974 from Patent EP1572962.
JD428544 - Sequence 409568 from Patent EP1572962.
JD109793 - Sequence 90817 from Patent EP1572962.
JD206490 - Sequence 187514 from Patent EP1572962.
JD301616 - Sequence 282640 from Patent EP1572962.
JD154748 - Sequence 135772 from Patent EP1572962.
JD315186 - Sequence 296210 from Patent EP1572962.
JD079965 - Sequence 60989 from Patent EP1572962.
JD186607 - Sequence 167631 from Patent EP1572962.
JD091887 - Sequence 72911 from Patent EP1572962.
LF345332 - JP 2014500723-A/152835: Polycomb-Associated Non-Coding RNAs.
LF345335 - JP 2014500723-A/152838: Polycomb-Associated Non-Coding RNAs.
LF345342 - JP 2014500723-A/152845: Polycomb-Associated Non-Coding RNAs.
LF345345 - JP 2014500723-A/152848: Polycomb-Associated Non-Coding RNAs.
MA580909 - JP 2018138019-A/152835: Polycomb-Associated Non-Coding RNAs.
MA580912 - JP 2018138019-A/152838: Polycomb-Associated Non-Coding RNAs.
MA580919 - JP 2018138019-A/152845: Polycomb-Associated Non-Coding RNAs.
MA580922 - JP 2018138019-A/152848: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q4ADV7 (Reactome details) participates in the following event(s):

R-HSA-6811428 RIC1:RGP1 recruits RAB6:GDP to the TGN
R-HSA-8847887 RAB33B:GTP binds RIC1:RGP1
R-HSA-6811431 RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
R-HSA-6811429 RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange
R-HSA-8876193 RIC1-RGP1 exchanges GTP for GDP on RAB6
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs
R-HSA-199991 Membrane Trafficking
R-HSA-9007101 Rab regulation of trafficking
R-HSA-5653656 Vesicle-mediated transport

-  Other Names for This Gene
  Alternate Gene Symbols: AL136875, CIP150, NM_020829, NP_065880, Q4ADV7-2, uc003zjh.1
UCSC ID: uc003zjh.2
RefSeq Accession: NM_001135920
Protein: Q4ADV7-2, splice isoform of Q4ADV7

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AL136875.1
exon count: 22CDS single in 3' UTR: no RNA size: 3623
ORF size: 3261CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 6587.50frame shift in genome: no % Coverage: 99.45
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: yes # AT/AC introns 0
selenocysteine: no end bleed into intron: 196# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.