Human Gene KIAA1432 (uc003zji.1) Description and Page Index
  Description: connexin 43-interacting protein 150 isoform a
Transcript (Including UTRs)
   Position: hg18 chr9:5,646,583-5,764,309 Size: 117,727 Total Exon Count: 25 Strand: +
Coding Region
   Position: hg18 chr9:5,646,676-5,764,246 Size: 117,571 Coding Exon Count: 25 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2009-03-03

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:5,646,583-5,764,309)mRNA (may differ from genome)Protein (1344 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDMGIOMIM
PubMedStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
  ID: RIC1_HUMAN
DESCRIPTION: RecName: Full=Protein RIC1 homolog; AltName: Full=Connexin-43-interacting protein of 150 kDa;
FUNCTION: Required for phosphorylation and localization of GJA1.
SUBUNIT: Interacts with GJA1.
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Present in kidney and various cell lines (at protein level). Widely expressed at low level.
SIMILARITY: Belongs to the RIC1 family.
SIMILARITY: Contains 2 WD repeats.
SEQUENCE CAUTION: Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Sequence=CAI95004.1; Type=Erroneous gene model prediction;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from U133A and GNF1H Chips

      
      
      
     
    
     
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.0093-0.215 Picture PostScript Text
3' UTR -19.1063-0.303 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009771 - Ribosome_control_1
IPR015943 - WD40/YVTN_repeat-like_dom
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF07064 - RIC1

SCOP Domains:
101898 - NHL repeat
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q4ADV7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details  Gene DetailsGene Details 
Gene Sorter  Gene SorterGene Sorter 
MGI EnsemblFlyBaseWormBase 
Protein Sequence Protein SequenceProtein SequenceProtein Sequence 
Alignment AlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017112 Rab guanyl-nucleotide exchange factor activity
GO:0017137 Rab GTPase binding

Biological Process:
GO:0006886 intracellular protein transport
GO:0042147 retrograde transport, endosome to Golgi
GO:0043547 positive regulation of GTPase activity
GO:1903363 negative regulation of cellular protein catabolic process

Cellular Component:
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
GO:0032991 macromolecular complex
GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex


-  Descriptions from all associated GenBank mRNAs
  AL136875 - Homo sapiens mRNA; cDNA DKFZp434D105 (from clone DKFZp434D105).
LF385283 - JP 2014500723-A/192786: Polycomb-Associated Non-Coding RNAs.
LF385475 - JP 2014500723-A/192978: Polycomb-Associated Non-Coding RNAs.
MA620860 - JP 2018138019-A/192786: Polycomb-Associated Non-Coding RNAs.
MA621052 - JP 2018138019-A/192978: Polycomb-Associated Non-Coding RNAs.
BC136616 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:168229 IMAGE:9020606), complete cds.
BC144296 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:177833 IMAGE:9052816), complete cds.
AB205401 - Homo sapiens CIP150 mRNA for connexin43-interacting protein of 150 kDa, complete cds.
AK124394 - Homo sapiens cDNA FLJ42403 fis, clone ASTRO3000177, weakly similar to Drosophila melanogaster BcDNA.GH03694 (BcDNA.GH03694) mRNA.
AK022642 - Homo sapiens cDNA FLJ12580 fis, clone NT2RM4001116, weakly similar to HYPOTHETICAL 216.3 KD PROTEIN R06F6.8 IN CHROMOSOME II.
AB037853 - Homo sapiens mRNA for KIAA1432 protein, partial cds.
AB527173 - Synthetic construct DNA, clone: pF1KA1432, Homo sapiens KIAA1432 gene for KIAA1432, without stop codon, in Flexi system.
AK074150 - Homo sapiens mRNA for FLJ00223 protein.
BC030576 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4077122), partial cds.
BC023535 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4123047), partial cds.
BC041044 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4901507), partial cds.
JD468950 - Sequence 449974 from Patent EP1572962.
JD428544 - Sequence 409568 from Patent EP1572962.
JD508053 - Sequence 489077 from Patent EP1572962.
JD109793 - Sequence 90817 from Patent EP1572962.
JD206490 - Sequence 187514 from Patent EP1572962.
JD301616 - Sequence 282640 from Patent EP1572962.
JD154748 - Sequence 135772 from Patent EP1572962.
JD315186 - Sequence 296210 from Patent EP1572962.
JD079965 - Sequence 60989 from Patent EP1572962.
JD186607 - Sequence 167631 from Patent EP1572962.
JD091887 - Sequence 72911 from Patent EP1572962.
JD051695 - Sequence 32719 from Patent EP1572962.
JD344563 - Sequence 325587 from Patent EP1572962.
LF345332 - JP 2014500723-A/152835: Polycomb-Associated Non-Coding RNAs.
LF345335 - JP 2014500723-A/152838: Polycomb-Associated Non-Coding RNAs.
LF345342 - JP 2014500723-A/152845: Polycomb-Associated Non-Coding RNAs.
LF345345 - JP 2014500723-A/152848: Polycomb-Associated Non-Coding RNAs.
LF345346 - JP 2014500723-A/152849: Polycomb-Associated Non-Coding RNAs.
LF345348 - JP 2014500723-A/152851: Polycomb-Associated Non-Coding RNAs.
LF345349 - JP 2014500723-A/152852: Polycomb-Associated Non-Coding RNAs.
MA580909 - JP 2018138019-A/152835: Polycomb-Associated Non-Coding RNAs.
MA580912 - JP 2018138019-A/152838: Polycomb-Associated Non-Coding RNAs.
MA580919 - JP 2018138019-A/152845: Polycomb-Associated Non-Coding RNAs.
MA580922 - JP 2018138019-A/152848: Polycomb-Associated Non-Coding RNAs.
MA580923 - JP 2018138019-A/152849: Polycomb-Associated Non-Coding RNAs.
MA580925 - JP 2018138019-A/152851: Polycomb-Associated Non-Coding RNAs.
MA580926 - JP 2018138019-A/152852: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RN24, B2RN24_HUMAN, NM_020829, NP_065880
UCSC ID: uc003zji.1
RefSeq Accession: NM_020829
Protein: Q4ADV7 (aka RIC1_HUMAN)
CCDS: CCDS34982.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020829.1
exon count: 25CDS single in 3' UTR: no RNA size: 4125
ORF size: 4035CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 8165.00frame shift in genome: no % Coverage: 99.88
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.