Human Gene KIAA1432 (uc003zji.1) Description and Page Index
Description: connexin 43-interacting protein 150 isoform a
Transcript (Including UTRs)
Position: hg18 chr9:5,646,583-5,764,309 Size: 117,727 Total Exon Count: 25 Strand: +
Position: hg18 chr9:5,646,676-5,764,246 Size: 117,571 Coding Exon Count: 25
Data last updated: 2009-03-03
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Protein RIC1 homolog; AltName: Full=Connexin-43-interacting protein of 150 kDa;
FUNCTION: Required for phosphorylation and localization of GJA1. SUBUNIT: Interacts with GJA1. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICITY: Present in kidney and various cell lines (at protein level). Widely expressed at low level. SIMILARITY: Belongs to the RIC1 family. SIMILARITY: Contains 2 WD repeats. SEQUENCE CAUTION: Sequence=AAI36617.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI44297.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14150.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE16982.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB66809.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI95003.1; Type=Erroneous gene model prediction; Sequence=CAI95004.1; Type=Erroneous gene model prediction;
Comparative Toxicogenomics Database (CTD)
Microarray Expression Data
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009771 - Ribosome_control_1
IPR015943 - WD40/YVTN_repeat-like_dom
IPR017986 - WD40_repeat_dom
Pfam Domains: PF07064 - RIC1
SCOP Domains: 101898 - NHL repeat
50969 - YVTN repeat-like/Quinoprotein amine dehydrogenase
50978 - WD40 repeat-like
50993 - Prolyl oligopeptidase, N-terminal domain
ModBase Predicted Comparative 3D Structure on Q4ADV7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AL136875 - Homo sapiens mRNA; cDNA DKFZp434D105 (from clone DKFZp434D105). LF385283 - JP 2014500723-A/192786: Polycomb-Associated Non-Coding RNAs. LF385475 - JP 2014500723-A/192978: Polycomb-Associated Non-Coding RNAs. MA620860 - JP 2018138019-A/192786: Polycomb-Associated Non-Coding RNAs. MA621052 - JP 2018138019-A/192978: Polycomb-Associated Non-Coding RNAs. BC136616 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:168229 IMAGE:9020606), complete cds. BC144296 - Homo sapiens KIAA1432, mRNA (cDNA clone MGC:177833 IMAGE:9052816), complete cds. AB205401 - Homo sapiens CIP150 mRNA for connexin43-interacting protein of 150 kDa, complete cds. AK124394 - Homo sapiens cDNA FLJ42403 fis, clone ASTRO3000177, weakly similar to Drosophila melanogaster BcDNA.GH03694 (BcDNA.GH03694) mRNA. AK022642 - Homo sapiens cDNA FLJ12580 fis, clone NT2RM4001116, weakly similar to HYPOTHETICAL 216.3 KD PROTEIN R06F6.8 IN CHROMOSOME II. AB037853 - Homo sapiens mRNA for KIAA1432 protein, partial cds. AB527173 - Synthetic construct DNA, clone: pF1KA1432, Homo sapiens KIAA1432 gene for KIAA1432, without stop codon, in Flexi system. AK074150 - Homo sapiens mRNA for FLJ00223 protein. BC030576 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4077122), partial cds. BC023535 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4123047), partial cds. BC041044 - Homo sapiens KIAA1432, mRNA (cDNA clone IMAGE:4901507), partial cds. JD468950 - Sequence 449974 from Patent EP1572962. JD428544 - Sequence 409568 from Patent EP1572962. JD508053 - Sequence 489077 from Patent EP1572962. JD109793 - Sequence 90817 from Patent EP1572962. JD206490 - Sequence 187514 from Patent EP1572962. JD301616 - Sequence 282640 from Patent EP1572962. JD154748 - Sequence 135772 from Patent EP1572962. JD315186 - Sequence 296210 from Patent EP1572962. JD079965 - Sequence 60989 from Patent EP1572962. JD186607 - Sequence 167631 from Patent EP1572962. JD091887 - Sequence 72911 from Patent EP1572962. JD051695 - Sequence 32719 from Patent EP1572962. JD344563 - Sequence 325587 from Patent EP1572962. LF345332 - JP 2014500723-A/152835: Polycomb-Associated Non-Coding RNAs. LF345335 - JP 2014500723-A/152838: Polycomb-Associated Non-Coding RNAs. LF345342 - JP 2014500723-A/152845: Polycomb-Associated Non-Coding RNAs. LF345345 - JP 2014500723-A/152848: Polycomb-Associated Non-Coding RNAs. LF345346 - JP 2014500723-A/152849: Polycomb-Associated Non-Coding RNAs. LF345348 - JP 2014500723-A/152851: Polycomb-Associated Non-Coding RNAs. LF345349 - JP 2014500723-A/152852: Polycomb-Associated Non-Coding RNAs. MA580909 - JP 2018138019-A/152835: Polycomb-Associated Non-Coding RNAs. MA580912 - JP 2018138019-A/152838: Polycomb-Associated Non-Coding RNAs. MA580919 - JP 2018138019-A/152845: Polycomb-Associated Non-Coding RNAs. MA580922 - JP 2018138019-A/152848: Polycomb-Associated Non-Coding RNAs. MA580923 - JP 2018138019-A/152849: Polycomb-Associated Non-Coding RNAs. MA580925 - JP 2018138019-A/152851: Polycomb-Associated Non-Coding RNAs. MA580926 - JP 2018138019-A/152852: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: B2RN24, B2RN24_HUMAN, NM_020829, NP_065880 UCSC ID: uc003zji.1 RefSeq Accession: NM_020829
(aka RIC1_HUMAN) Q4ADV7
Gene Model Information
25 CDS single in 3' UTR:
4035 CDS single in intron:
Alignment % ID:
8165.00 frame shift in genome:
has start codon:
stop codon in genome:
# of Alignments:
has end codon:
# AT/AC introns
end bleed into intron:
0 # strange splices:
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.