Mouse Gene Per1 (ENSMUST00000101004.8) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Per1 (from geneSymbol)
RefSeq Summary (NM_001159367): This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014].
Gencode Transcript: ENSMUST00000101004.8
Gencode Gene: ENSMUSG00000020893.17
Transcript (Including UTRs)
   Position: mm10 chr11:69,095,217-69,106,458 Size: 11,242 Total Exon Count: 18 Strand: +
Coding Region
   Position: mm10 chr11:69,100,642-69,105,655 Size: 5,014 Coding Exon Count: 17 

Page IndexSequence and LinksCTDRNA StructureProtein StructureOther Species
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:69,095,217-69,106,458)mRNA (may differ from genome)Protein (827 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsMGIPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.30220-0.310 Picture PostScript Text
3' UTR -288.22803-0.359 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001610 - PAC
IPR000014 - PAS
IPR013655 - PAS_fold_3

Pfam Domains:
PF08447 - PAS fold
PF14598 - PAS domain

SCOP Domains:
55785 - PYP-like sensor domain (PAS domain)

ModBase Predicted Comparative 3D Structure on Q8C4K7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK081813 - Mus musculus 16 days embryo head cDNA, RIKEN full-length enriched library, clone:C130078P18 product:period homolog (Drosophila), full insert sequence.
AK087212 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030034J16 product:PER1 (FRAGMENT), full insert sequence.
AK154900 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630110N16 product:period homolog 1 (Drosophila), full insert sequence.
BC091645 - Mus musculus period homolog 1 (Drosophila), mRNA (cDNA clone MGC:102121 IMAGE:30355259), complete cds.
AK148202 - Mus musculus B16 F10Y cells cDNA, RIKEN full-length enriched library, clone:G370049C23 product:period homolog 1 (Drosophila), full insert sequence.
AK172958 - Mus musculus mRNA for mKIAA0482 protein.
BC039768 - Mus musculus period homolog 1 (Drosophila), mRNA (cDNA clone MGC:49546 IMAGE:4163009), complete cds.
AB002108 - Mus musculus mPer mRNA, complete cds.
AK182563 - Mus musculus cDNA, clone:Y0G0123A04, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000021271, based on BLAT search.
AF022992 - Mus musculus Rigui mRNA, complete cds.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04710 - Circadian rhythm - mammal

BioCarta from NCI Cancer Genome Anatomy Project
m_circadianPathway - Circadian Rhythms

-  Other Names for This Gene
  Alternate Gene Symbols: AK081813, Q8C4K7, Q8C4K7_MOUSE, RP23-26L6.6-003, uc007jpf.1, uc007jpf.2
UCSC ID: uc007jpf.2
RefSeq Accession: NM_001159367
Protein: Q8C4K7

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.