Mouse Gene Ppp3cb (uc007sjy.2) Description and Page Index
  Description: serine/threonine-protein phosphatase 2B
Transcript (Including UTRs)
   Position: mm9 chr14:21,318,536-21,365,795 Size: 47,260 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm9 chr14:21,320,706-21,365,662 Size: 44,957 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:21,318,536-21,365,795)mRNA (may differ from genome)Protein (524 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: E0CZ78_MOUSE
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase; EC=3.1.3.16;
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
SIMILARITY: Belongs to the PPP phosphatase family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -50.10133-0.377 Picture PostScript Text
3' UTR -530.482170-0.244 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004843 - Metallo_PEstase_dom
IPR006186 - Ser/Thr-sp_prot-phosphatase

Pfam Domains:
PF00149 - Calcineurin-like phosphoesterase

SCOP Domains:
56300 - Metallo-dependent phosphatases

ModBase Predicted Comparative 3D Structure on E0CZ78
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity

Biological Process:
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001946 lymphangiogenesis
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007507 heart development
GO:0010468 regulation of gene expression
GO:0017156 calcium ion regulated exocytosis
GO:0030217 T cell differentiation
GO:0031987 locomotion involved in locomotory behavior
GO:0034097 response to cytokine
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043029 T cell homeostasis

Cellular Component:
GO:0005886 plasma membrane
GO:0030018 Z disc
GO:0030315 T-tubule


-  Descriptions from all associated GenBank mRNAs
  BC037668 - Mus musculus protein phosphatase 3, catalytic subunit, beta isoform, mRNA (cDNA clone IMAGE:5375983), partial cds.
BC066000 - Mus musculus protein phosphatase 3, catalytic subunit, beta isoform, mRNA (cDNA clone MGC:91348 IMAGE:5699179), complete cds.
M81483 - Mus musculus calmodulin dependent phosphatase catalytic subunit (Cam-Prp) mRNA, 3' end.
AB221678 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01Y045G15.
AK135203 - Mus musculus 12 days embryo male wolffian duct includes surrounding region cDNA, RIKEN full-length enriched library, clone:6720421K10 product:protein phosphatase 3, catalytic subunit, beta isoform, full insert sequence.
AK037615 - Mus musculus 16 days neonate thymus cDNA, RIKEN full-length enriched library, clone:A130029N01 product:protein phosphatase 3, catalytic subunit, beta isoform, full insert sequence.
AK004360 - Mus musculus 18-day embryo whole body cDNA, RIKEN full-length enriched library, clone:1110063J16 product:protein phosphatase 3, catalytic subunit, beta isoform, full insert sequence.
BC049860 - Mus musculus protein phosphatase 3, catalytic subunit, beta isoform, mRNA (cDNA clone IMAGE:5003539), partial cds.
AK019060 - Mus musculus adult male stomach cDNA, RIKEN full-length enriched library, clone:2210404A05 product:Homo sapiens protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) (PPP3CB), mRNA, full insert sequence.
AK171904 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830018L06 product:Protein phosphatase 3 catalytic subunit beta3 (EC 3.1.3.16) (Serine/threonine protein phosphatase) homolog [Homo sapiens], full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04010 - MAPK signaling pathway
mmu04020 - Calcium signaling pathway
mmu04114 - Oocyte meiosis
mmu04210 - Apoptosis
mmu04310 - Wnt signaling pathway
mmu04360 - Axon guidance
mmu04370 - VEGF signaling pathway
mmu04380 - Osteoclast differentiation
mmu04650 - Natural killer cell mediated cytotoxicity
mmu04660 - T cell receptor signaling pathway
mmu04662 - B cell receptor signaling pathway
mmu04720 - Long-term potentiation
mmu05010 - Alzheimer's disease
mmu05014 - Amyotrophic lateral sclerosis (ALS)

BioCarta from NCI Cancer Genome Anatomy Project
m_mef2dPathway - Role of MEF2D in T-cell Apoptosis
m_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
m_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
m_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
m_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin
m_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
m_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
m_gpcrPathway - Signaling Pathway from G-Protein Families
m_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation
m_nos1Pathway - Nitric Oxide Signaling Pathway
m_tcrPathway - T Cell Receptor Signaling Pathway
m_bcrPathway - BCR Signaling Pathway
m_pgc1aPathway - Regulation of PGC-1a

-  Other Names for This Gene
  Alternate Gene Symbols: AB221678, E0CZ78, E0CZ78_MOUSE, NM_008914, NP_032940, uc007sjy.1
UCSC ID: uc007sjy.2
RefSeq Accession: NM_008914
Protein: E0CZ78 CCDS: CCDS26846.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AB221678.1
exon count: 14CDS single in 3' UTR: no RNA size: 1575
ORF size: 1575CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3246.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.