Mouse Gene Sardh (uc008ixg.1) Description and Page Index
  Description: sarcosine dehydrogenase, mitochondrial
Transcript (Including UTRs)
   Position: mm9 chr2:27,044,902-27,102,332 Size: 57,431 Total Exon Count: 21 Strand: -
Coding Region
   Position: mm9 chr2:27,045,039-27,100,022 Size: 54,984 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:27,044,902-27,102,332)mRNA (may differ from genome)Protein (919 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkMGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q3TWI2_MOUSE
DESCRIPTION: SubName: Full=Sarcosine dehydrogenase;
SIMILARITY: Belongs to the GcvT family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
Ratios
        
Absolute

GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.80181-0.325 Picture PostScript Text
3' UTR -43.30137-0.316 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006076 - FAD-dep_OxRdtase
IPR013977 - GCV_T_C
IPR006222 - GCV_T_N

Pfam Domains:
PF01266 - FAD dependent oxidoreductase
PF01571 - Aminomethyltransferase folate-binding domain
PF08669 - Glycine cleavage T-protein C-terminal barrel domain

SCOP Domains:
101790 - Aminomethyltransferase beta-barrel domain
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain
103025 - Aminomethyltransferase folate-binding domain

ModBase Predicted Comparative 3D Structure on Q3TWI2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
Gene SorterGene Sorter Gene Sorter  
GenBankRGDEnsemblFlyBase  
Protein SequenceProtein SequenceProtein SequenceProtein Sequence  
AlignmentAlignmentAlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0016491 oxidoreductase activity

Biological Process:
GO:0055114 oxidation-reduction process


-  Descriptions from all associated GenBank mRNAs
  AK163515 - Mus musculus adult male corpora quadrigemina cDNA, RIKEN full-length enriched library, clone:B230329P17 product:sarcosine dehydrogenase, full insert sequence.
AK140451 - Mus musculus 10 days neonate medulla oblongata cDNA, RIKEN full-length enriched library, clone:B830031F14 product:sarcosine dehydrogenase, full insert sequence.
AK163660 - Mus musculus 10 days neonate medulla oblongata cDNA, RIKEN full-length enriched library, clone:B830034M20 product:sarcosine dehydrogenase, full insert sequence.
AK087163 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030030M09 product:SARCOSINE DEHYDROGENASE (EC 1.5.99.1) homolog [Rattus norvegicus], full insert sequence.
AK159236 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420011E21 product:sarcosine dehydrogenase, full insert sequence.
AK159681 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420028C06 product:sarcosine dehydrogenase, full insert sequence.
AK159704 - Mus musculus osteoclast-like cell cDNA, RIKEN full-length enriched library, clone:I420028J16 product:sarcosine dehydrogenase, full insert sequence.
BC003456 - Mus musculus sarcosine dehydrogenase, mRNA (cDNA clone MGC:6279 IMAGE:2648344), complete cds.
AK213212 - Mus musculus cDNA, clone:Y2G0127J10, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000063833, based on BLAT search.
AK194323 - Mus musculus cDNA, clone:Y1G0114P17, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000063833, based on BLAT search.
AK178634 - Mus musculus cDNA, clone:Y0G0107G16, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK183193 - Mus musculus cDNA, clone:Y0G0125A15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK176928 - Mus musculus cDNA, clone:Y0G0101A07, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK182037 - Mus musculus cDNA, clone:Y0G0120J09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK208205 - Mus musculus cDNA, clone:Y2G0110H02, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK180924 - Mus musculus cDNA, clone:Y0G0116F15, strand:minus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK192092 - Mus musculus cDNA, clone:Y1G0107N09, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.
AK213849 - Mus musculus cDNA, clone:Y2G0129L11, strand:plus, reference:ENSEMBL:Mouse-Transcript-ENST:ENSMUST00000009758, based on BLAT search.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00260 - Glycine, serine and threonine metabolism
mmu01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: mCG_128379, NM_138665, NP_619606, Q3TWI2, Q3TWI2_MOUSE, RP23-171K6.2-001
UCSC ID: uc008ixg.1
RefSeq Accession: NM_138665
Protein: Q3TWI2 CCDS: CCDS15826.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_138665.1
exon count: 21CDS single in 3' UTR: no RNA size: 3093
ORF size: 2760CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 5518.50frame shift in genome: no % Coverage: 99.52
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.