Mouse Gene Npr2 (uc008sqp.1) Description and Page Index
  Description: atrial natriuretic peptide receptor 2 precursor
Transcript (Including UTRs)
   Position: mm9 chr4:43,656,898-43,664,112 Size: 7,215 Total Exon Count: 12 Strand: +
Coding Region
   Position: mm9 chr4:43,656,955-43,663,850 Size: 6,896 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:43,656,898-43,664,112)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: B1AWJ0_MOUSE
DESCRIPTION: RecName: Full=Guanylate cyclase; EC=4.6.1.2; Flags: Fragment;
CATALYTIC ACTIVITY: GTP = 3',5'-cyclic GMP + diphosphate.
SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
Ratios
    
     
      
       
     
    
   
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Absolute

Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
Ratios
        
Absolute

Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR 0.00570.000 Picture PostScript Text
3' UTR -54.15262-0.207 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001054 - A/G_cyclase
IPR018297 - A/G_cyclase_CS
IPR011645 - Haem_no_assoc-bd
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF00211 - Adenylate and Guanylate cyclase catalytic domain
PF07701 - Heme NO binding associated
PF07714 - Protein tyrosine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)
55073 - Adenylyl and guanylyl cyclase catalytic domain

ModBase Predicted Comparative 3D Structure on B1AWJ0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BC042470 - Mus musculus natriuretic peptide receptor 2, mRNA (cDNA clone MGC:30424 IMAGE:5137261), complete cds.
LF194360 - JP 2014500723-A/1863: Polycomb-Associated Non-Coding RNAs.
MA429937 - JP 2018138019-A/1863: Polycomb-Associated Non-Coding RNAs.
AK158195 - Mus musculus adult inner ear cDNA, RIKEN full-length enriched library, clone:F930041A15 product:natriuretic peptide receptor 2, full insert sequence.
BC037458 - Mus musculus natriuretic peptide receptor 2, mRNA (cDNA clone IMAGE:4159633), partial cds.
BC049896 - Mus musculus natriuretic peptide receptor 2, mRNA (cDNA clone IMAGE:3986402), containing frame-shift errors.
BC023420 - Mus musculus natriuretic peptide receptor 2, mRNA (cDNA clone IMAGE:5052434), partial cds.
LF271254 - JP 2014500723-A/78757: Polycomb-Associated Non-Coding RNAs.
LF271255 - JP 2014500723-A/78758: Polycomb-Associated Non-Coding RNAs.
MA506831 - JP 2018138019-A/78757: Polycomb-Associated Non-Coding RNAs.
MA506832 - JP 2018138019-A/78758: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00230 - Purine metabolism
mmu04270 - Vascular smooth muscle contraction

-  Other Names for This Gene
  Alternate Gene Symbols: B1AWJ0, B1AWJ0_MOUSE, BC049896, NM_173788, NP_776149, RP23-191F22.6-004
UCSC ID: uc008sqp.1
RefSeq Accession: NM_173788
Protein: B1AWJ0

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC049896.1
exon count: 12CDS single in 3' UTR: no RNA size: 1765
ORF size: 1434CDS single in intron: no Alignment % ID: 99.89
txCdsPredict score: 2968.00frame shift in genome: no % Coverage: 99.21
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 57# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.