Mouse Gene Iqsec3 (uc009dom.1) Description and Page Index
  Description: IQ motif and SEC7 domain-containing protein 3
Transcript (Including UTRs)
   Position: mm9 chr6:121,322,951-121,423,696 Size: 100,746 Total Exon Count: 14 Strand: -
Coding Region
   Position: mm9 chr6:121,326,088-121,423,581 Size: 97,494 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:121,322,951-121,423,696)mRNA (may differ from genome)Protein (1195 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkMGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=IQ motif and SEC7 domain-containing protein 3;
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for ARF1 (By similarity).
SUBUNIT: Interacts with DLG1 and DLG4 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Expressed specifically in the adult brain, but not in the fetal brain at 14 dpc.
SIMILARITY: Belongs to the BRAG family.
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 SEC7 domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
Expression ratio colors:

GNF Expression Atlas Data from U74b Mouse Chip


Affymetrix All Exon Microarrays


-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -63.00115-0.548 Picture PostScript Text
3' UTR -1145.373137-0.365 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR000904 - Sec7
IPR023394 - SEC7_alpha_orthog

Pfam Domains:
PF01369 - Sec7 domain

SCOP Domains:
48425 - Sec7 domain
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q3TES0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
Protein SequenceProtein SequenceProtein Sequence   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding

Biological Process:
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0090630 activation of GTPase activity

Cellular Component:
GO:0005737 cytoplasm
GO:0045211 postsynaptic membrane
GO:0060077 inhibitory synapse

-  Descriptions from all associated GenBank mRNAs
  AK147351 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M5C1018J21 product:similar to capicua (Drosophila) homolog [Homo sapiens], full insert sequence.
AK122446 - Mus musculus mRNA for mKIAA1110 protein.
AK169437 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M421501D06 product:similar to capicua (Drosophila) homolog [Homo sapiens], full insert sequence.
BC168388 - Synthetic construct Mus musculus clone IMAGE:100068357, MGC:195901 IQ motif and Sec7 domain 3 (Iqsec3) mRNA, encodes complete protein.
AK147268 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M5C1004I05 product:similar to capicua (Drosophila) homolog [Homo sapiens], full insert sequence.
AK161923 - Mus musculus adult male olfactory brain cDNA, RIKEN full-length enriched library, clone:6430408C08 product:unclassifiable, full insert sequence.
BC114639 - Mus musculus cDNA clone IMAGE:40086579.
BC128502 - Mus musculus cDNA clone IMAGE:40086589.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu04144 - Endocytosis

-  Other Names for This Gene
  Alternate Gene Symbols: IQEC3_MOUSE, Kiaa1110, NM_001033354, NP_001028526, Q3TES0, Q3UHP8, Q80TJ8
UCSC ID: uc009dom.1
RefSeq Accession: NM_001033354
Protein: Q3TES0 (aka IQEC3_MOUSE)
CCDS: CCDS20491.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_001033354.2
exon count: 14CDS single in 3' UTR: no RNA size: 6840
ORF size: 3588CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 7350.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.