Human Gene SLC2A13 (uc010skm.2)
  Description: Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 13 (SLC2A13), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr12:40,148,823-40,499,661 Size: 350,839 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr12:40,153,828-40,499,610 Size: 345,783 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:40,148,823-40,499,661)mRNA (may differ from genome)Protein (648 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedReactomeTreefamUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: MYCT_HUMAN
DESCRIPTION: RecName: Full=Proton myo-inositol cotransporter; Short=H(+)-myo-inositol cotransporter; Short=Hmit; AltName: Full=H(+)-myo-inositol symporter;
FUNCTION: H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Predominantly expressed in the brain.
PTM: Glycosylated.
SIMILARITY: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
SEQUENCE CAUTION: Sequence=AAI17118.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAI17120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC51116.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC2A13
CDC HuGE Published Literature: SLC2A13
Positive Disease Associations: Body Height , Echocardiography , Forced Vital Capacity , Hemoglobins , Hip , Parkinson Disease
Related Studies:
  1. Body Height
    , , . [PubMed 0]
  2. Body Height
    , , . [PubMed 0]
  3. Body Height
    , , . [PubMed 0]
           more ... click here to view the complete list

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.77 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 114.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -23.2051-0.455 Picture PostScript Text
3' UTR -1129.995005-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR005828 - Sub_transporter
IPR003663 - Sugar/inositol_transpt
IPR005829 - Sugar_transporter_CS

Pfam Domains:
PF00083 - Sugar (and other) transporter
PF07690 - Major Facilitator Superfamily

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on Q96QE2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
  Ensembl WormBaseSGD
  Protein Sequence Protein SequenceProtein Sequence
  Alignment AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005351 sugar:proton symporter activity
GO:0005355 glucose transmembrane transporter activity
GO:0005366 myo-inositol:proton symporter activity
GO:0022857 transmembrane transporter activity

Biological Process:
GO:0015798 myo-inositol transport
GO:0046323 glucose import
GO:0055085 transmembrane transport
GO:1902600 hydrogen ion transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AJ315644 - Homo sapiens mRNA for proton myo-inositol symporter (Hmit gene).
BC117117 - Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 13, mRNA (cDNA clone MGC:150726 IMAGE:40125668), complete cds.
BC117119 - Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 13, mRNA (cDNA clone MGC:150728 IMAGE:40125670), complete cds.
KJ904962 - Synthetic construct Homo sapiens clone ccsbBroadEn_14356 SLC2A13 gene, encodes complete protein.
KJ905597 - Synthetic construct Homo sapiens clone ccsbBroadEn_15223 SLC2A13 gene, encodes complete protein.
AK000182 - Homo sapiens cDNA FLJ20175 fis, clone COL09869.
BC047507 - Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 13, mRNA (cDNA clone MGC:48624 IMAGE:5272386), complete cds.
KJ903637 - Synthetic construct Homo sapiens clone ccsbBroadEn_13031 SLC2A13 gene, encodes complete protein.
AK026495 - Homo sapiens cDNA: FLJ22842 fis, clone KAIA4958.
BC039431 - Homo sapiens cDNA clone IMAGE:5303419.
JD236653 - Sequence 217677 from Patent EP1572962.
JD239135 - Sequence 220159 from Patent EP1572962.
JD207825 - Sequence 188849 from Patent EP1572962.
JD274314 - Sequence 255338 from Patent EP1572962.
JD362150 - Sequence 343174 from Patent EP1572962.
JD150157 - Sequence 131181 from Patent EP1572962.
JD541422 - Sequence 522446 from Patent EP1572962.
JD502794 - Sequence 483818 from Patent EP1572962.
JD094764 - Sequence 75788 from Patent EP1572962.
JD393002 - Sequence 374026 from Patent EP1572962.
JD290664 - Sequence 271688 from Patent EP1572962.
JD470686 - Sequence 451710 from Patent EP1572962.
JD395664 - Sequence 376688 from Patent EP1572962.
JD125821 - Sequence 106845 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96QE2 (Reactome details) participates in the following event(s):

R-HSA-429101 HMIT co-transports myo-inositol with a proton
R-HSA-429593 Inositol transporters
R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: MYCT_HUMAN, NM_052885, NP_443117, Q17S07, Q96QE2
UCSC ID: uc010skm.2
RefSeq Accession: NM_052885
Protein: Q96QE2 (aka MYCT_HUMAN)
CCDS: CCDS8736.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_052885.3
exon count: 10CDS single in 3' UTR: no RNA size: 7018
ORF size: 1947CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3991.00frame shift in genome: no % Coverage: 99.79
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.