Human Gene TAF8 (uc011dun.2) Description and Page Index
  Description: Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa (TAF8), mRNA.
RefSeq Summary (NM_138572): This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.214491.1, SRR1803614.40703.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372977.8/ ENSP00000362068.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##
Transcript (Including UTRs)
   Position: hg19 chr6:42,018,658-42,048,644 Size: 29,987 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr6:42,019,239-42,045,283 Size: 26,045 Coding Exon Count: 8 

Page IndexSequence and LinksGenetic AssociationsMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr6:42,018,658-42,048,644)mRNA (may differ from genome)Protein (234 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
PubMedStanford SOURCETreefamUniProtKBWikipedia

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TAF8
CDC HuGE Published Literature: TAF8

-  MalaCards Disease Associations
  MalaCards Gene Search: TAF8
Diseases sorted by gene-association score: poland syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.38 RPKM in Thyroid
Total median expression: 122.38 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.20376-0.301 Picture PostScript Text
3' UTR -1404.993361-0.418 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006565 - BTP
IPR019473 - TFIID_su8_C

Pfam Domains:
PF07524 - Bromodomain associated
PF10406 - Transcription factor TFIID complex subunit 8 C-term

ModBase Predicted Comparative 3D Structure on B4DZU5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
     Protein Sequence

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046982 protein heterodimerization activity

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex

-  Descriptions from all associated GenBank mRNAs
  BC033728 - Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa, mRNA (cDNA clone IMAGE:5166848), with apparent retained intron.
BC119678 - Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa, mRNA (cDNA clone MGC:149563 IMAGE:40116287), complete cds.
BC119679 - Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa, mRNA (cDNA clone MGC:149564 IMAGE:40116290), complete cds.
AK057383 - Homo sapiens cDNA FLJ32821 fis, clone TESTI2003005, highly similar to Mus musculus taube nuss mRNA.
AL833401 - Homo sapiens mRNA; cDNA DKFZp313E0720 (from clone DKFZp313E0720).
BC018796 - Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa, mRNA (cDNA clone IMAGE:3027950), with apparent retained intron.
AF465841 - Homo sapiens TBP-associated factor TAFII43 (TAFII43) mRNA, complete cds.
CU689710 - Synthetic construct Homo sapiens gateway clone IMAGE:100018150 5' read TAF8 mRNA.
KJ903752 - Synthetic construct Homo sapiens clone ccsbBroadEn_13146 TAF8 gene, encodes complete protein.
KJ903753 - Synthetic construct Homo sapiens clone ccsbBroadEn_13147 TAF8 gene, encodes complete protein.
AK303097 - Homo sapiens cDNA FLJ57866 complete cds, highly similar to Homo sapiens TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, mRNA.
DL491588 - Novel nucleic acids.
DL490183 - Novel nucleic acids.
JD505070 - Sequence 486094 from Patent EP1572962.
JD526580 - Sequence 507604 from Patent EP1572962.
JD322311 - Sequence 303335 from Patent EP1572962.
AF086309 - Homo sapiens full length insert cDNA clone ZD51E07.
JD120620 - Sequence 101644 from Patent EP1572962.
JD379800 - Sequence 360824 from Patent EP1572962.
JD094194 - Sequence 75218 from Patent EP1572962.
JD094195 - Sequence 75219 from Patent EP1572962.
JD245958 - Sequence 226982 from Patent EP1572962.
JD220922 - Sequence 201946 from Patent EP1572962.
JD489171 - Sequence 470195 from Patent EP1572962.
JD489172 - Sequence 470196 from Patent EP1572962.
JD254666 - Sequence 235690 from Patent EP1572962.
JD264542 - Sequence 245566 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK303097, B4DZU5, B4DZU5_HUMAN, NM_138572, NP_612639
UCSC ID: uc011dun.2
RefSeq Accession: NM_138572
Protein: B4DZU5

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: AK303097.1
exon count: 9CDS single in 3' UTR: no RNA size: 1178
ORF size: 705CDS single in intron: no Alignment % ID: 99.83
txCdsPredict score: 1495.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.