Mouse Gene Acss3 (uc011xna.1) Description and Page Index
  Description: acyl-CoA synthetase short-chain family member 3,
Transcript (Including UTRs)
   Position: mm9 chr10:106,373,220-106,560,720 Size: 187,501 Total Exon Count: 16 Strand: -
Coding Region
   Position: mm9 chr10:106,373,220-106,560,639 Size: 187,420 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:106,373,220-106,560,720)mRNA (may differ from genome)Protein (682 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAllen Brain Atlas
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
MGIPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ACSS3_MOUSE
DESCRIPTION: RecName: Full=Acyl-CoA synthetase short-chain family member 3, mitochondrial; EC=6.2.1.1; Flags: Precursor;
FUNCTION: Activates acetate so that it can be used for lipid synthesis or for energy generation (By similarity).
CATALYTIC ACTIVITY: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
SUBCELLULAR LOCATION: Mitochondrion (Potential).
SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Absolute

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.8081-0.306 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024597 - Acyl-CoA_synth_DUF3448
IPR020845 - AMP-binding_CS
IPR000873 - AMP-dep_Synth/Lig
IPR025110 - DUF4009

Pfam Domains:
PF00501 - AMP-binding enzyme

SCOP Domains:
56801 - Acetyl-CoA synthetase-like

ModBase Predicted Comparative 3D Structure on Q14DH7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologGenome BrowserGenome BrowserNo orthologNo ortholog
Gene Details  Gene Details  
Gene Sorter  Gene Sorter  
GenBank EnsemblFlyBase  
Protein Sequence Protein SequenceProtein Sequence  
Alignment AlignmentAlignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0003987 acetate-CoA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity

Biological Process:
GO:0008150 biological_process
GO:0008152 metabolic process

Cellular Component:
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  AK033376 - Mus musculus 16 days embryo lung cDNA, RIKEN full-length enriched library, clone:8430416H19 product:weakly similar to ACETYL-COA SYNTHETASE [Rhizobium loti], full insert sequence.
BC113198 - Mus musculus acyl-CoA synthetase short-chain family member 3, mRNA (cDNA clone MGC:132986 IMAGE:40062399), complete cds.
AK163897 - Mus musculus 0 day neonate cerebellum cDNA, RIKEN full-length enriched library, clone:C230030D12 product:Weakly similar to acetyl-CoA synthetase homolog [Mus musculus], full insert sequence.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
mmu00640 - Propanoate metabolism
mmu01100 - Metabolic pathways

BioCyc Knowledge Library
PWY0-1313 - acetate conversion to acetyl-CoA
PWY66-21 - ethanol degradation II (cytosol)

Reactome (by CSHL, EBI, and GO)

Protein Q14DH7 (Reactome details) participates in the following event(s):

R-MMU-8875071 ACSS3 ligates CoA to CH3COO-
R-MMU-77111 Synthesis of Ketone Bodies
R-MMU-74182 Ketone body metabolism
R-MMU-556833 Metabolism of lipids
R-MMU-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: ACSS3_MOUSE, NM_001142804, NP_001136276, Q14DH7, Q8BZX0, uc007gyv.1
UCSC ID: uc011xna.1
RefSeq Accession: NM_001142804
Protein: Q14DH7 (aka ACSS3_MOUSE)
CCDS: CCDS48688.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001142804.1
exon count: 16CDS single in 3' UTR: no RNA size: 2130
ORF size: 2049CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4150.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.