ID:PP2BB_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; EC=184.108.40.206; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit beta isoform; FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate. COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity). COFACTOR: Binds 1 zinc ion per subunit (By similarity). SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. INTERACTION: Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-1759540, EBI-6117042; P14316:IRF2; NbExp=2; IntAct=EBI-1759540, EBI-2866589; SIMILARITY: Belongs to the PPP phosphatase family. PP-2B subfamily.
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PPP3CB CDC HuGE Published Literature: PPP3CB
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16298
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.