Human Gene PPP3CB (uc001jue.3) Description and Page Index
  Description: Homo sapiens protein phosphatase 3, catalytic subunit, beta isozyme (PPP3CB), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr10:75,196,563-75,255,782 Size: 59,220 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr10:75,198,000-75,255,647 Size: 57,648 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated: 2013-06-14

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:75,196,563-75,255,782)mRNA (may differ from genome)Protein (524 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
OMIMPubMedReactomeStanford SOURCETreefamUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; EC=; AltName: Full=CAM-PRP catalytic subunit; AltName: Full=Calmodulin-dependent calcineurin A subunit beta isoform;
FUNCTION: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein + phosphate.
COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity).
COFACTOR: Binds 1 zinc ion per subunit (By similarity).
SUBUNIT: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.
INTERACTION: Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-1759540, EBI-6117042; P14316:IRF2; NbExp=2; IntAct=EBI-1759540, EBI-2866589;
SIMILARITY: Belongs to the PPP phosphatase family. PP-2B subfamily.

-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PPP3CB
CDC HuGE Published Literature: PPP3CB

-  MalaCards Disease Associations
  MalaCards Gene Search: PPP3CB
Diseases sorted by gene-association score: cardiomyopathy, familial hypertrophic (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 46.97 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 828.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -55.49135-0.411 Picture PostScript Text
3' UTR -384.161437-0.267 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004843 - Metallo_PEstase_dom
IPR006186 - Ser/Thr-sp_prot-phosphatase

Pfam Domains:
PF00149 - Calcineurin-like phosphoesterase

SCOP Domains:
56300 - Metallo-dependent phosphatases

ModBase Predicted Comparative 3D Structure on P16298
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008144 drug binding
GO:0016787 hydrolase activity
GO:0019899 enzyme binding
GO:0030346 protein phosphatase 2B binding
GO:0033192 calmodulin-dependent protein phosphatase activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity

Biological Process:
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001946 lymphangiogenesis
GO:0006468 protein phosphorylation
GO:0006470 protein dephosphorylation
GO:0007165 signal transduction
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0007507 heart development
GO:0007612 learning
GO:0007613 memory
GO:0010468 regulation of gene expression
GO:0016311 dephosphorylation
GO:0017156 calcium ion regulated exocytosis
GO:0030217 T cell differentiation
GO:0031987 locomotion involved in locomotory behavior
GO:0033173 calcineurin-NFAT signaling cascade
GO:0034097 response to cytokine
GO:0035176 social behavior
GO:0035690 cellular response to drug
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0043029 T cell homeostasis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048167 regulation of synaptic plasticity
GO:0048675 axon extension
GO:0050796 regulation of insulin secretion

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005955 calcineurin complex
GO:0030018 Z disc
GO:0030315 T-tubule

-  Descriptions from all associated GenBank mRNAs
  BC035464 - Homo sapiens protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform, mRNA (cDNA clone IMAGE:4540083).
BC028049 - Homo sapiens protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform, mRNA (cDNA clone MGC:39903 IMAGE:4538822), complete cds.
AJ488506 - Homo sapiens mRNA for protein phosphatase 3 catalytic subunit beta3 (PPP3CB gene).
M29551 - Human calcineurin A2 mRNA, complete cds.
KJ891874 - Synthetic construct Homo sapiens clone ccsbBroadEn_01268 PPP3CB gene, encodes complete protein.
AB489159 - Synthetic construct DNA, clone: pF1KB4148, Homo sapiens PPP3CB gene for protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform, without stop codon, in Flexi system.
M29550 - Human calcineurin A1 mRNA, complete cds.
AK301582 - Homo sapiens cDNA FLJ60928 complete cds, highly similar to Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC
JD376576 - Sequence 357600 from Patent EP1572962.
JD166419 - Sequence 147443 from Patent EP1572962.
JD279446 - Sequence 260470 from Patent EP1572962.
AK300701 - Homo sapiens cDNA FLJ53100 complete cds, highly similar to Serine/threonine-protein phosphatase 2Bcatalytic subunit beta isoform (EC
JD344504 - Sequence 325528 from Patent EP1572962.
JD090229 - Sequence 71253 from Patent EP1572962.
JD291358 - Sequence 272382 from Patent EP1572962.
JD494643 - Sequence 475667 from Patent EP1572962.
JD475571 - Sequence 456595 from Patent EP1572962.
JD315558 - Sequence 296582 from Patent EP1572962.
JD294559 - Sequence 275583 from Patent EP1572962.
JD140784 - Sequence 121808 from Patent EP1572962.
JD523642 - Sequence 504666 from Patent EP1572962.
JD291685 - Sequence 272709 from Patent EP1572962.
JD391294 - Sequence 372318 from Patent EP1572962.
JD320513 - Sequence 301537 from Patent EP1572962.
JD456711 - Sequence 437735 from Patent EP1572962.
JD060007 - Sequence 41031 from Patent EP1572962.
AB209251 - Homo sapiens mRNA for Na+/K+ -ATPase alpha 3 subunit variant protein.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04010 - MAPK signaling pathway
hsa04020 - Calcium signaling pathway
hsa04114 - Oocyte meiosis
hsa04210 - Apoptosis
hsa04310 - Wnt signaling pathway
hsa04360 - Axon guidance
hsa04370 - VEGF signaling pathway
hsa04650 - Natural killer cell mediated cytotoxicity
hsa04660 - T cell receptor signaling pathway
hsa04662 - B cell receptor signaling pathway
hsa04720 - Long-term potentiation
hsa05010 - Alzheimer's disease
hsa05014 - Amyotrophic lateral sclerosis (ALS)

BioCarta from NCI Cancer Genome Anatomy Project
h_fMLPpathway - fMLP induced chemokine gene expression in HMC-1 cells
h_mef2dPathway - Role of MEF2D in T-cell Apoptosis
h_nfatPathway - NFAT and Hypertrophy of the heart (Transcription in the broken heart)
h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin
h_tcrPathway - T Cell Receptor Signaling Pathway
h_bcrPathway - BCR Signaling Pathway
h_calcineurinPathway - Effects of calcineurin in Keratinocyte Differentiation
h_pgc1aPathway - Regulation of PGC-1a
h_hdacPathway - Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
h_vipPathway - Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells
h_fcer1Pathway - Fc Epsilon Receptor I Signaling in Mast Cells
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_nos1Pathway - Nitric Oxide Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P16298 (Reactome details) participates in the following event(s):

R-HSA-9010645 AKAP5 recruits PPP3CB (PP2BB) to ROBO2
R-HSA-201783 Inactive catalytic PP2B is activated by the binding of calmodulin
R-HSA-2025890 Calcineurin binds NFATC1,2,3
R-HSA-2730872 Activation of Calcineurin
R-HSA-201787 PPP3 complex dephosphorylates DARPP-32 on Thr34
R-HSA-4551451 Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling
R-HSA-2730867 Translocation of CaN:CaM:NFAT to nucleus
R-HSA-9010642 ROBO receptors bind AKAP5
R-HSA-376176 Signaling by ROBO receptors
R-HSA-180024 DARPP-32 events
R-HSA-422475 Axon guidance
R-HSA-111885 Opioid Signalling
R-HSA-2025928 Calcineurin activates NFAT
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-4086398 Ca2+ pathway
R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-HSA-1266738 Developmental Biology
R-HSA-418594 G alpha (i) signalling events
R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-3858494 Beta-catenin independent WNT signaling
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-388396 GPCR downstream signalling
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-168249 Innate Immune System
R-HSA-195721 Signaling by WNT
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-372790 Signaling by GPCR
R-HSA-1280218 Adaptive Immune System
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: CALNA2, CALNB, CNA2, NM_021132, NP_066955, P16298, P16299, PP2BB_HUMAN, Q5F2F9, Q8N1F0, Q8N3W4
UCSC ID: uc001jue.3
RefSeq Accession: NM_021132
Protein: P16298 (aka PP2BB_HUMAN)
CCDS: CCDS7328.1, CCDS44436.1, CCDS44437.1

-  Gene Model Information
category: coding nonsense-mediated-decay: no RNA accession: NM_021132.2
exon count: 14CDS single in 3' UTR: no RNA size: 3164
ORF size: 1575CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3302.00frame shift in genome: no % Coverage: 99.46
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.