Mouse Gene Ambra1 (ENSMUST00000045699.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
Description: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. (from UniProt A2AH22) Gencode Transcript: ENSMUST00000045699.7 Gencode Gene: ENSMUSG00000040506.16 Transcript (Including UTRs) Position: mm10 chr2:91,766,445-91,918,849 Size: 152,405 Total Exon Count: 17 Strand: + Coding Region Position: mm10 chr2:91,766,566-91,917,823 Size: 151,258 Coding Exon Count: 17
ID:AMRA1_MOUSE DESCRIPTION: RecName: Full=Activating molecule in BECN1-regulated autophagy protein 1; FUNCTION: Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. SUBUNIT: Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3. SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome (Probable). DEVELOPMENTAL STAGE: At E8.5, it is detected throughout the neuroepithelium. At E11.5, it is highly expressed in the ventral- most part of the spinal cord, the encephalic vesicles, the neural retina, the limbs and the dorsal root ganglia. Later, it is expressed in the entire developing nervous system as well as in other tissues. In brain, strong expression is observed in the cortex, hippocampus and striatum of postnatal brain. DISRUPTION PHENOTYPE: Mice display severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death. SIMILARITY: Contains 3 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A2AH22
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
