ID:ACE2_MOUSE DESCRIPTION: RecName: Full=Angiotensin-converting enzyme 2; EC=184.108.40.206; AltName: Full=ACE-related carboxypeptidase; Contains: RecName: Full=Processed angiotensin-converting enzyme 2; Flags: Precursor; FUNCTION: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury. CATALYTIC ACTIVITY: Angiotensin II + H(2)O = angiotensin-(1-7) + L-phenylalanine. COFACTOR: Binds 1 zinc ion per subunit (By similarity). COFACTOR: Binds 1 chloride ion per subunit (By similarity). SUBUNIT: Weakly interacts with SARS-CoV S protein. SUBCELLULAR LOCATION: Processed angiotensin-converting enzyme 2: Secreted (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells. INDUCTION: Down-regulated in lung after acute injury. PTM: Proteolytic cleavage by ADAM17 generates a secreted form (By similarity). DISRUPTION PHENOTYPE: Mice are viable and fertile, exhibit normal kidney and lung function, but show a severe reduction in cardiac contractility, and are highly sensitive to severe acute lung failure. Transgenic mice overexpressing ACE2 in the heart appear healthy but show conduction disturbances and ventricular arrhythmias which can lead to sudden death. SEQUENCE CAUTION: Sequence=BAB40431.1; Type=Frameshift; Positions=784;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8R0I0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.