Mouse Gene Foxp1 (ENSMUST00000176632.7) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)
  Description: Contains 1 fork-head DNA-binding domain. (from UniProt H3BL33)
Gencode Transcript: ENSMUST00000176632.7
Gencode Gene: ENSMUSG00000030067.17
Transcript (Including UTRs)
   Position: mm10 chr6:98,930,090-99,435,345 Size: 505,256 Total Exon Count: 19 Strand: -
Coding Region
   Position: mm10 chr6:98,930,090-99,163,018 Size: 232,929 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2019-09-19

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:98,930,090-99,435,345)mRNA (may differ from genome)Protein (674 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGeneCardsMGIPubMed
SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: H3BL33_MOUSE
DESCRIPTION: SubName: Full=Forkhead box protein P1;
SIMILARITY: Contains 1 fork-head DNA-binding domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -107.40311-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001766 - TF_fork_head
IPR018122 - TF_fork_head_CS
IPR011991 - WHTH_trsnscrt_rep_DNA-bd
IPR015880 - Znf_C2H2-like

Pfam Domains:
PF00250 - Forkhead domain
PF16159 - FOXP coiled-coil domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on H3BL33
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002329 pre-B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0008045 motor neuron axon guidance
GO:0021517 ventral spinal cord development
GO:0030324 lung development
GO:0033152 immunoglobulin V(D)J recombination
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061140 lung secretory cell differentiation
GO:0061470 T follicular helper cell differentiation
GO:0072358 cardiovascular system development
GO:0072619 interleukin-21 secretion
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK035794 - Mus musculus 16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630004O19 product:unclassifiable, full insert sequence.
AK033368 - Mus musculus 16 days embryo lung cDNA, RIKEN full-length enriched library, clone:8430407G20 product:forkhead box P1, full insert sequence.
AK077062 - Mus musculus adult male testis cDNA, RIKEN full-length enriched library, clone:4932443N09 product:forkhead box P1, full insert sequence.
AB594192 - Mus musculus Foxp1a mRNA for forkhead-related transcription factor 1A, complete cds.
BC064764 - Mus musculus forkhead box P1, mRNA (cDNA clone MGC:76591 IMAGE:30430449), complete cds.
AF339105 - Mus musculus forkhead-related transcription factor 1C (Foxp1c) mRNA, complete cds.
AB221601 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X014A13.
AB221602 - Mus musculus cDNA pooled tissues:(tissue_type=brain,dev_stage=8-12 days neonate,strain=BALB/c),(tissue_type=testis,dev_stage=adult, strain=C57BL/6J), clone:V01X014A15.
AF339103 - Mus musculus forkhead-related transcription factor 1A (Foxp1a) mRNA, complete cds.
AF339104 - Mus musculus forkhead-related transcription factor 1B (Foxp1b) mRNA, complete cds.
AK031837 - Mus musculus adult male medulla oblongata cDNA, RIKEN full-length enriched library, clone:6330416B21 product:forkhead box P1, full insert sequence.
AK139831 - Mus musculus 2 cells egg cDNA, RIKEN full-length enriched library, clone:B020023N10 product:forkhead box P1, full insert sequence.
BC065386 - Mus musculus forkhead box P1, mRNA (cDNA clone IMAGE:850460), complete cds.
AK171994 - Mus musculus activated spleen cDNA, RIKEN full-length enriched library, clone:F830028D12 product:forkhead box P1, full insert sequence.
AK040800 - Mus musculus adult male aorta and vein cDNA, RIKEN full-length enriched library, clone:A530025P03 product:forkhead box P1, full insert sequence.
AK051887 - Mus musculus 12 days embryo eyeball cDNA, RIKEN full-length enriched library, clone:D230015H16 product:unclassifiable, full insert sequence.
AK160315 - Mus musculus 16 days embryo lung cDNA, RIKEN full-length enriched library, clone:8430401A19 product:forkhead box P1, full insert sequence.
AK087748 - Mus musculus 2 days pregnant adult female ovary cDNA, RIKEN full-length enriched library, clone:E330015F20 product:unclassifiable, full insert sequence.
EF410101 - Mus musculus Accn1/Foxp1 trans-spliced mRNA sequence.
AK144920 - Mus musculus mammary gland RCB-0526 Jyg-MC(A) cDNA, RIKEN full-length enriched library, clone:G830003K13 product:forkhead box P1, full insert sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: AB594192, H3BL33, H3BL33_MOUSE, uc291hjv.1
UCSC ID: uc291hjv.1
RefSeq Accession: NM_053202
Protein: H3BL33 CCDS: CCDS39578.1, CCDS57442.1, CCDS85105.1

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.