S. cerevisiae Gene TAF8 (YML114C) Description and Page Index
  Description: TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
Transcript (Including UTRs)
   Position: sacCer3 chrXIII:42,043-43,575 Size: 1,533 Total Exon Count: 1 Strand: -
Coding Region
   Position: sacCer3 chrXIII:42,043-43,575 Size: 1,533 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther SpeciesGO Annotations
Other NamesMethods
Data last updated: 2011-08-29

-  Sequence and Links to Tools and Databases
Genomic Sequence (chrXIII:42,043-43,575)mRNAProtein (510 aa)
Gene SorterGenome BrowserOther Species FASTASGDUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 8; AltName: Full=TAFII-65; AltName: Full=TBP-associated factor 65 kDa; AltName: Full=TBP-associated factor 8;
FUNCTION: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
SUBUNIT: In TFIID, TAF8 heterodimerizes with TAF10. The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14.
INTERACTION: Q12030:TAF10; NbExp=7; IntAct=EBI-27947, EBI-18889;
MISCELLANEOUS: Present with 4684 (+/-522) molecules/cell in log phase SD medium.
SIMILARITY: Belongs to the TAF8 family.
SIMILARITY: Contains 1 histone-fold domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019473 - TFIID_su8_C

Pfam Domains:
PF10406 - Transcription factor TFIID complex subunit 8 C-term

ModBase Predicted Comparative 3D Structure on Q03750
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanMouseRatZebrafishD. melanogasterC. elegans
Genome BrowserNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene Details   Gene DetailsGene Details
Gene Sorter   Gene SorterGene Sorter
GenBank  EnsemblFlyBaseWormBase
Protein Sequence   Protein SequenceProtein Sequence
Alignment   AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly

Cellular Component:
GO:0005634 nucleus
GO:0005669 transcription factor TFIID complex

-  Other Names for This Gene
Protein: Q03750 (aka TAF8_YEAST)

-  SGD Genes Methods, Credits, and Data Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.