Human Gene FABP4 (ENST00000256104.5) from GENCODE V44
Description: Homo sapiens fatty acid binding protein 4 (FABP4), mRNA. (from RefSeq NM_001442) RefSeq Summary (NM_001442): FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000256104.5 Gencode Gene: ENSG00000170323.9 Transcript (Including UTRs) Position: hg38 chr8:81,478,419-81,483,233 Size: 4,815 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:81,478,865-81,483,167 Size: 4,303 Coding Exon Count: 4
ID:FABP4_HUMAN DESCRIPTION: RecName: Full=Fatty acid-binding protein, adipocyte; AltName: Full=Adipocyte lipid-binding protein; Short=ALBP; AltName: Full=Adipocyte-type fatty acid-binding protein; Short=A-FABP; Short=AFABP; AltName: Full=Fatty acid-binding protein 4; FUNCTION: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). SUBUNIT: Homodimer. Interacts with PPARG (By similarity). Monomer. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P15090
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001816 cytokine production GO:0006469 negative regulation of protein kinase activity GO:0019433 triglyceride catabolic process GO:0042632 cholesterol homeostasis GO:0045892 negative regulation of transcription, DNA-templated GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050872 white fat cell differentiation GO:0050873 brown fat cell differentiation GO:0071285 cellular response to lithium ion GO:0071356 cellular response to tumor necrosis factor
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