Human Gene CHKA (ENST00000356135.9) from GENCODE V44
Description: Homo sapiens choline kinase alpha (CHKA), transcript variant 2, mRNA. (from RefSeq NM_212469) RefSeq Summary (NM_212469): The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000356135.9 Gencode Gene: ENSG00000110721.12 Transcript (Including UTRs) Position: hg38 chr11:68,053,820-68,121,444 Size: 67,625 Total Exon Count: 11 Strand: - Coding Region Position: hg38 chr11:68,053,988-68,121,177 Size: 67,190 Coding Exon Count: 11
ID:CHKA_HUMAN DESCRIPTION: RecName: Full=Choline kinase alpha; Short=CK; EC=2.7.1.32; AltName: Full=CHETK-alpha; AltName: Full=Ethanolamine kinase; Short=EK; EC=2.7.1.82; FUNCTION: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. CATALYTIC ACTIVITY: ATP + choline = ADP + phosphocholine. CATALYTIC ACTIVITY: ATP + ethanolamine = ADP + O- phosphoethanolamine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.2 mM for choline; KM=0.4 mM for ATP; KM=12 mM for ethanolamine; PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1. PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. SUBUNIT: Heterodimer with CHKB (By similarity). Homodimer. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the choline/ethanolamine kinase family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CHKAID44009ch11q13.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P35790
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006580 ethanolamine metabolic process GO:0006629 lipid metabolic process GO:0006646 phosphatidylethanolamine biosynthetic process GO:0006656 phosphatidylcholine biosynthetic process GO:0006657 CDP-choline pathway GO:0006869 lipid transport GO:0007165 signal transduction GO:0008654 phospholipid biosynthetic process GO:0009636 response to toxic substance GO:0016310 phosphorylation GO:0019695 choline metabolic process GO:1904681 response to 3-methylcholanthrene
US Server
