Human Gene TIMM8B (ENST00000541231.1) from GENCODE V44
Description: translocase of inner mitochondrial membrane 8 homolog B (from HGNC TIMM8B) RefSeq Summary (NM_012459): This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]. Gencode Transcript: ENST00000541231.1 Gencode Gene: ENSG00000150779.12 Transcript (Including UTRs) Position: hg38 chr11:112,084,817-112,086,798 Size: 1,982 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr11:112,085,295-112,086,768 Size: 1,474 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02953 - Tim10/DDP family zinc finger
ModBase Predicted Comparative 3D Structure on G3XAN8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.