Mouse Gene Klf5 (uc007uvf.1) Description and Page Index
  Description: Krueppel-like factor 5
Transcript (Including UTRs)
   Position: mm9 chr14:99,697,910-99,704,550 Size: 6,641 Total Exon Count: 3 Strand: +
Coding Region
   Position: mm9 chr14:99,698,235-99,702,704 Size: 4,470 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel Information
Methods
Data last updated: 2011-03-02

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:99,697,910-99,704,550)mRNA (may differ from genome)Protein (382 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
MGIPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: KLF5_MOUSE
DESCRIPTION: RecName: Full=Krueppel-like factor 5; AltName: Full=Basic transcription element-binding protein 2; Short=BTE-binding protein 2; AltName: Full=Intestinal-enriched krueppel-like factor; AltName: Full=Transcription factor BTEB2;
FUNCTION: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes.
SUBUNIT: Interacts with WWP1 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highest expression in digestive track.
PTM: Ubiquitinated (By similarity). Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 3 C2H2-type zinc fingers.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  Microarray Expression Data
 
Expression ratio colors:

GNF Expression Atlas 2 Data from GNF1M Mouse Chip

    
     
      
       
     
    
   
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Rinn et. al Sex Gene Expression Data on MOE430A Chip

        
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GNF Expression Atlas Data from U74a Mouse Chip

        
     
    
    
    
   
    
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Affymetrix All Exon Microarrays

           
Ratios

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -177.01325-0.545 Picture PostScript Text
3' UTR -537.141846-0.291 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q9Z0Z7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
HumanRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
GenBankRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0008284 positive regulation of cell proliferation
GO:0030033 microvillus assembly
GO:0032534 regulation of microvillus assembly
GO:0035914 skeletal muscle cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060576 intestinal epithelial cell development
GO:0071407 cellular response to organic cyclic compound
GO:1901653 cellular response to peptide
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000723 negative regulation of cardiac vascular smooth muscle cell differentiation

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK142985 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030028G21 product:Kruppel-like factor 5, full insert sequence.
AK051409 - Mus musculus 12 days embryo spinal ganglion cDNA, RIKEN full-length enriched library, clone:D130046N09 product:Kruppel-like factor 5, full insert sequence.
BC011307 - Mus musculus cDNA clone IMAGE:3708183, containing frame-shift errors.
BC012958 - Mus musculus Kruppel-like factor 5, mRNA (cDNA clone MGC:13705 IMAGE:4208633), complete cds.
AB025099 - Mus musculus mRNA for BTE-binding protein 2, complete cds.
AF079852 - Mus musculus intestinal-enriched Kruppel-like factor IKLF mRNA, complete cds.
AK087066 - Mus musculus 0 day neonate lung cDNA, RIKEN full-length enriched library, clone:E030024K03 product:Kruppel-like factor 5, full insert sequence.
BC006646 - Mus musculus Kruppel-like factor 5, mRNA (cDNA clone MGC:7725 IMAGE:3498207), complete cds.
AK079283 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530082L07 product:inferred: Kruppel-like factor 5 / Unknown (protein for MGC:7725) [Mus musculus], full insert sequence.
LF200115 - JP 2014500723-A/7618: Polycomb-Associated Non-Coding RNAs.
LF205021 - JP 2014500723-A/12524: Polycomb-Associated Non-Coding RNAs.
LF200116 - JP 2014500723-A/7619: Polycomb-Associated Non-Coding RNAs.
LF242410 - JP 2014500723-A/49913: Polycomb-Associated Non-Coding RNAs.
LF242411 - JP 2014500723-A/49914: Polycomb-Associated Non-Coding RNAs.
LF242419 - JP 2014500723-A/49922: Polycomb-Associated Non-Coding RNAs.
LF242420 - JP 2014500723-A/49923: Polycomb-Associated Non-Coding RNAs.
LF242421 - JP 2014500723-A/49924: Polycomb-Associated Non-Coding RNAs.
LF242422 - JP 2014500723-A/49925: Polycomb-Associated Non-Coding RNAs.
LF242423 - JP 2014500723-A/49926: Polycomb-Associated Non-Coding RNAs.
LF242425 - JP 2014500723-A/49928: Polycomb-Associated Non-Coding RNAs.
LF242426 - JP 2014500723-A/49929: Polycomb-Associated Non-Coding RNAs.
LF242427 - JP 2014500723-A/49930: Polycomb-Associated Non-Coding RNAs.
LF242428 - JP 2014500723-A/49931: Polycomb-Associated Non-Coding RNAs.
MA435692 - JP 2018138019-A/7618: Polycomb-Associated Non-Coding RNAs.
MA440598 - JP 2018138019-A/12524: Polycomb-Associated Non-Coding RNAs.
MA477987 - JP 2018138019-A/49913: Polycomb-Associated Non-Coding RNAs.
MA477988 - JP 2018138019-A/49914: Polycomb-Associated Non-Coding RNAs.
MA477996 - JP 2018138019-A/49922: Polycomb-Associated Non-Coding RNAs.
MA477997 - JP 2018138019-A/49923: Polycomb-Associated Non-Coding RNAs.
MA477998 - JP 2018138019-A/49924: Polycomb-Associated Non-Coding RNAs.
MA477999 - JP 2018138019-A/49925: Polycomb-Associated Non-Coding RNAs.
MA478000 - JP 2018138019-A/49926: Polycomb-Associated Non-Coding RNAs.
MA435693 - JP 2018138019-A/7619: Polycomb-Associated Non-Coding RNAs.
MA478002 - JP 2018138019-A/49928: Polycomb-Associated Non-Coding RNAs.
MA478003 - JP 2018138019-A/49929: Polycomb-Associated Non-Coding RNAs.
MA478004 - JP 2018138019-A/49930: Polycomb-Associated Non-Coding RNAs.
MA478005 - JP 2018138019-A/49931: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC006646, Bteb2, Iklf, KLF5_MOUSE, NM_009769, NP_033899, Q9JMI2, Q9Z0Z7
UCSC ID: uc007uvf.1
RefSeq Accession: NM_009769
Protein: Q9Z0Z7 (aka KLF5_MOUSE)

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC006646.1
exon count: 3CDS single in 3' UTR: no RNA size: 2907
ORF size: 1149CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2477.00frame shift in genome: no % Coverage: 98.28
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 1854# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.