Nat Cell Biol 2000, PMID: 10783243

TRAIL receptor-2 signals apoptosis through FADD and caspase-8.

Bodmer, J L; Holler, N; Reynard, S; Vinciguerra, P; Schneider, P; Juo, P; Blenis, J; Tschopp, J

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Text Mining Data

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Manually curated Databases

• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → Caspase 8 (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, inhibits)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → Caspase 8 (tetramer) complex (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → Caspase 8 (tetramer) complex (CASP8) (modification, collaborate)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → Caspase 8 (CASP8) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: sTNF-alpha/TNFR1A/TRADD/TRAF2/FADD complex (TNFRSF1A-TRADD-TRAF2-FADD-TNF) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) (modification, collaborate)
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR1 complex (TNFRSF10A-TNFSF10) (modification, collaborate)
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) → TRAIL/TRAILR1 complex (TNFRSF10A-TNFSF10) (modification, collaborate)
  Evidence: physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → Caspase 8 (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: c-FLIP (CFLAR) → Caspase 8 (tetramer) complex (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → Caspase 8 (tetramer) complex (CASP8) (modification, collaborate)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR2 complex (TNFRSF10B-TNFSF10) (modification, collaborate)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: FADD (FADD) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR2 complex (TNFRSF10B-TNFSF10) → TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) (modification, collaborate)
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Erk1-2-active (MAPK3/MAPK1) → Caspase 8 (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Erk1-2-active (MAPK3/MAPK1) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Erk1-2-active (MAPK3/MAPK1) → Caspase 8 (tetramer) complex (CASP8) (modification, inhibits)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) (modification, collaborate)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: Caspase 8 (CASP8) → Caspase 8 (tetramer) complex (CASP8) (modification, collaborate)
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database TRAIL signaling pathway: TRAIL/TRAILR1/DAP3/GTP/FADD complex (TNFRSF10A-FADD-TNFSF10-DAP3) → Caspase 8 (tetramer) complex (CASP8) (modification, activates)
  Evidence: mutant phenotype, assay, physical interaction

In total, 71 gene pairs are associated to this article in curated databases