Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2000, PMID: 10851237

Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).

Friesen, W J; Dreyfuss, G

The spinal muscular atrophy disease gene product (SMN) is crucial for small nuclear ribonuclear protein (snRNP) biogenesis in the cytoplasm and plays a role in pre-mRNA splicing in the nucleus. SMN oligomers interact avidly with the snRNP core proteins SmB, -D1, and -D3. We have delineated the specific sequences in the Sm proteins that mediate their interaction with SMN. We show that unique carboxyl-terminal arginine- and glycine-rich domains comprising the last 29 amino acids of SmD1 and the last 32 amino acids of SmD3 are necessary and sufficient for SMN binding. Interestingly, SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6. Furthermore, the carboxyl-terminal arginine- and glycine-rich domain of Lsm4 directly interacts with SMN. This suggests that SMN also functions in the assembly of the U6 snRNP in the nucleus and in the assembly of other Lsm-containing complexes. These findings demonstrate that arginine- and glycine-rich domains are necessary and sufficient for SMN interaction, and they expand further the range of targets of the SMN protein.

Diseases/Pathways annotated by Medline MESH: Muscular Atrophy, Spinal
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

  • IRef Biogrid Interaction: SNRPD1 — SMN1 (direct interaction, pull down)
  • IRef Biogrid Interaction: LSM2 — SMN1 (direct interaction, pull down)
  • IRef Biogrid Interaction: SNRPD3 — SMN1 (direct interaction, pull down)
  • IRef Biogrid Interaction: SMN1 — LSM7 (direct interaction, pull down)
  • IRef Biogrid Interaction: LSM4 — SMN1 (direct interaction, pull down)
  • IRef Biogrid Interaction: LSM6 — SMN1 (direct interaction, pull down)
  • IRef Hprd Interaction: LSM3 — SMN1 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM2 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM7 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM4 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM6 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM5 (in vitro)
  • IRef Hprd Interaction: SMN1 — LSM1 (in vitro)
  • IRef Ophid Interaction: SMN2, SMN1 — LSM2 (aggregation, confirmational text mining)
  • IRef Ophid Interaction: SMN2, SMN1 — LSM7 (aggregation, confirmational text mining)
  • IRef Ophid Interaction: LSM4 — SMN2, SMN1 (aggregation, confirmational text mining)
  • IRef Ophid Interaction: LSM5 — SMN2, SMN1 (aggregation, confirmational text mining)
  • Reactome Reaction: SNRPD2 → GEMIN7 (reaction)
  • Reactome Reaction: SNRPB → SNRPD2 (reaction)
  • Reactome Reaction: SNRPF → PRMT5 (reaction)
  • Reactome Reaction: SNRPB → SNRPD3 (reaction)
  • Reactome Reaction: SNRPD3 → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD1 → SMN1 (reaction)
  • Reactome Reaction: CLNS1A → SNRPE (reaction)
  • Reactome Reaction: SNRPG → SMN1 (reaction)
  • Reactome Reaction: SNRPB → DDX20 (indirect_complex)
  • Reactome Reaction: SNRPB → DDX20 (reaction)
  • Reactome Reaction: SNRPD2 → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPE → GEMIN6 (indirect_complex)
  • Reactome Reaction: SNRPG → GEMIN5 (indirect_complex)
  • Reactome Reaction: GEMIN6 → WDR77 (reaction)
  • Reactome Reaction: SNRPF → WDR77 (reaction)
  • Reactome Reaction: SNRPD1 → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPD3 → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPE → SNRPF (reaction)
  • Reactome Reaction: CLNS1A → SNRPD3 (reaction)
  • Reactome Reaction: CLNS1A → GEMIN5 (reaction)
  • Reactome Reaction: CLNS1A → SNRPD1 (reaction)
  • Reactome Reaction: SNRPD1 → PRMT5 (reaction)
  • Reactome Reaction: SNRPD2 → SMN1 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPD2 (reaction)
  • Reactome Reaction: SNRPE → WDR77 (reaction)
  • Reactome Reaction: CLNS1A → SMN1 (reaction)
  • Reactome Reaction: SNRPD2 → DDX20 (reaction)
  • Reactome Reaction: SNRPE → SNRPG (reaction)
  • Reactome Reaction: SNRPG → GEMIN7 (reaction)
  • Reactome Reaction: CLNS1A → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD1 → SMN1 (indirect_complex)
  • Reactome Reaction: SNRPD2 → GEMIN7 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPB (indirect_complex)
  • Reactome Reaction: SNRPD1 → GEMIN7 (indirect_complex)
  • Reactome Reaction: SNRPB → PRMT5 (reaction)
  • Reactome Reaction: SNRPE → DDX20 (indirect_complex)
  • Reactome Reaction: SNRPE → GEMIN5 (indirect_complex)
  • Reactome Reaction: SNRPG → GEMIN6 (indirect_complex)
  • Reactome Reaction: SNRPD3 → GEMIN6 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPG (reaction)
  • Reactome Reaction: SNRPE → GEMIN7 (reaction)
  • Reactome Reaction: GEMIN7 → PRMT5 (reaction)
  • Reactome Reaction: SNRPD1 → SNRPE (reaction)
  • Reactome Reaction: CLNS1A → DDX20 (reaction)
  • Reactome Reaction: SNRPD1 → SNRPG (reaction)
  • Reactome Reaction: SNRPD2 → PRMT5 (reaction)
  • Reactome Reaction: DDX20 → WDR77 (reaction)
  • Reactome Reaction: SNRPD3 → GEMIN7 (reaction)
  • Reactome Reaction: SNRPD2 → GEMIN4 (reaction)
  • Reactome Reaction: CLNS1A → SNRPF (reaction)
  • Reactome Reaction: SNRPD3 → SMN1 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPD3 (indirect_complex)
  • Reactome Reaction: SNRPD2 → GEMIN6 (reaction)
  • Reactome Reaction: SNRPF → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPD1 → DDX20 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPD1 (reaction)
  • Reactome Reaction: SNRPD2 → SMN1 (reaction)
  • Reactome Reaction: SNRPD1 → SNRPD2 (reaction)
  • Reactome Reaction: SNRPB → SMN1 (indirect_complex)
  • Reactome Reaction: SNRPB → WDR77 (reaction)
  • Reactome Reaction: SNRPF → GEMIN7 (reaction)
  • Reactome Reaction: SNRPE → GEMIN7 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPG (indirect_complex)
  • Reactome Reaction: GEMIN4 → WDR77 (reaction)
  • Reactome Reaction: SNRPB → SNRPF (reaction)
  • Reactome Reaction: SNRPB → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD3 → WDR77 (reaction)
  • Reactome Reaction: SNRPD1 → SNRPF (reaction)
  • Reactome Reaction: SNRPF → GEMIN5 (reaction)
  • Reactome Reaction: SNRPE → SMN1 (indirect_complex)
  • Reactome Reaction: SNRPD3 → GEMIN5 (indirect_complex)
  • Reactome Reaction: SNRPD3 → GEMIN6 (reaction)
  • Reactome Reaction: SNRPF → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD3 → GEMIN5 (reaction)
  • Reactome Reaction: SNRPF → SMN1 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPF (indirect_complex)
  • Reactome Reaction: SNRPD2 → SNRPD3 (reaction)
  • Reactome Reaction: GEMIN2 → SNRPD1 (indirect_complex)
  • Reactome Reaction: SNRPF → GEMIN6 (reaction)
  • Reactome Reaction: SMN1 → WDR77 (reaction)
  • Reactome Reaction: GEMIN5 → PRMT5 (reaction)
  • Reactome Reaction: SNRPD2 → GEMIN6 (indirect_complex)
  • Reactome Reaction: SNRPD3 → GEMIN7 (indirect_complex)
  • Reactome Reaction: SNRPG → GEMIN5 (reaction)
  • Reactome Reaction: GEMIN4 → PRMT5 (reaction)
  • Reactome Reaction: SNRPE → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD1 → DDX20 (reaction)
  • Reactome Reaction: SNRPE → DDX20 (reaction)
  • Reactome Reaction: GEMIN2 → SNRPD2 (indirect_complex)
  • Reactome Reaction: CLNS1A → GEMIN2 (reaction)
  • Reactome Reaction: GEMIN2 → SNRPD3 (reaction)
  • Reactome Reaction: GEMIN2 → SNRPE (reaction)
  • Reactome Reaction: SNRPE → GEMIN5 (reaction)
  • Reactome Reaction: DDX20 → PRMT5 (reaction)
  • Reactome Reaction: SMN1 → PRMT5 (reaction)
  • Reactome Reaction: CLNS1A → SNRPB (reaction)
  • Reactome Reaction: SNRPE → GEMIN6 (reaction)
  • Reactome Reaction: SNRPE → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPD2 → SNRPF (reaction)
  • Reactome Reaction: SNRPD1 → WDR77 (reaction)
  • Reactome Reaction: SNRPF → GEMIN6 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPF (reaction)
  • Reactome Reaction: SNRPD1 → GEMIN5 (indirect_complex)
  • Reactome Reaction: SNRPB → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPD1 → GEMIN6 (indirect_complex)
  • Reactome Reaction: GEMIN5 → WDR77 (reaction)
  • Reactome Reaction: SNRPD2 → SNRPG (reaction)
  • Reactome Reaction: SNRPG → DDX20 (reaction)
  • Reactome Reaction: SNRPD1 → GEMIN7 (reaction)
  • Reactome Reaction: SNRPG → GEMIN7 (indirect_complex)
  • Reactome Reaction: SNRPF → SNRPG (reaction)
  • Reactome Reaction: SNRPD2 → DDX20 (indirect_complex)
  • Reactome Reaction: SNRPF → SMN1 (reaction)
  • Reactome Reaction: SNRPD2 → GEMIN5 (reaction)
  • Reactome Reaction: SNRPB → GEMIN7 (indirect_complex)
  • Reactome Reaction: SNRPD3 → SNRPG (reaction)
  • Reactome Reaction: SNRPG → WDR77 (reaction)
  • Reactome Reaction: SNRPG → DDX20 (indirect_complex)
  • Reactome Reaction: SNRPD3 → SMN1 (reaction)
  • Reactome Reaction: GEMIN7 → WDR77 (reaction)
  • Reactome Reaction: SNRPD2 → SNRPE (reaction)
  • Reactome Reaction: SNRPE → SMN1 (reaction)
  • Reactome Reaction: SNRPD3 → SNRPF (reaction)
  • Reactome Reaction: SNRPD1 → GEMIN6 (reaction)
  • Reactome Reaction: GEMIN6 → PRMT5 (reaction)
  • Reactome Reaction: SNRPD3 → PRMT5 (reaction)
  • Reactome Reaction: SNRPD1 → GEMIN4 (reaction)
  • Reactome Reaction: SNRPD2 → GEMIN5 (indirect_complex)
  • Reactome Reaction: CLNS1A → SNRPG (reaction)
  • Reactome Reaction: SNRPD3 → SNRPE (reaction)
  • Reactome Reaction: SNRPF → GEMIN5 (indirect_complex)
  • Reactome Reaction: SNRPD1 → GEMIN5 (reaction)
  • Reactome Reaction: SNRPG → GEMIN6 (reaction)
  • Reactome Reaction: CLNS1A → SNRPD2 (reaction)
  • Reactome Reaction: SNRPB → GEMIN5 (indirect_complex)
  • Reactome Reaction: SNRPB → GEMIN6 (indirect_complex)
  • Reactome Reaction: SNRPF → DDX20 (indirect_complex)
  • Reactome Reaction: GEMIN2 → SNRPE (indirect_complex)
  • Reactome Reaction: SNRPE → PRMT5 (reaction)
  • Reactome Reaction: SNRPG → GEMIN4 (reaction)
  • Reactome Reaction: CLNS1A → GEMIN7 (reaction)
  • Reactome Reaction: SNRPD3 → DDX20 (reaction)
  • Reactome Reaction: SNRPB → SNRPE (reaction)
  • Reactome Reaction: SNRPD1 → SNRPD3 (reaction)
  • Reactome Reaction: SNRPD2 → WDR77 (reaction)
  • Reactome Reaction: CLNS1A → GEMIN6 (reaction)
  • Reactome Reaction: SNRPB → GEMIN7 (reaction)
  • Reactome Reaction: SNRPB → SNRPG (reaction)
  • Reactome Reaction: SNRPB → GEMIN5 (reaction)
  • Reactome Reaction: SNRPF → GEMIN7 (indirect_complex)
  • Reactome Reaction: SNRPB → SMN1 (reaction)
  • Reactome Reaction: GEMIN2 → WDR77 (reaction)
  • Reactome Reaction: SNRPD3 → DDX20 (indirect_complex)
  • Reactome Reaction: GEMIN2 → PRMT5 (reaction)
  • Reactome Reaction: GEMIN2 → SNRPB (reaction)
  • Reactome Reaction: SNRPG → PRMT5 (reaction)
  • Reactome Reaction: SNRPB → SNRPD1 (reaction)
  • Reactome Reaction: SNRPB → GEMIN6 (reaction)
  • Reactome Reaction: SNRPG → GEMIN4 (indirect_complex)
  • Reactome Reaction: SNRPF → DDX20 (reaction)
  • Reactome Reaction: SNRPG → SMN1 (indirect_complex)
In total, 123 gene pairs are associated to this article in curated databases