UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

Nat Rev Mol Cell Biol 2000, PMID: 11252893

The many substrates and functions of ATM.

Kastan, M B; Lim, D S

As its name suggests, the ATM--'ataxia-telangiectasia, mutated'--gene is responsible for the rare disorder ataxia-telangiectasia. Patients show various abnormalities, mainly in their responses to DNA damage, but also in other cellular processes. Although it is hard to understand how a single gene product is involved in so many physiological processes, a clear picture is starting to emerge.

Diseases/Pathways annotated by Medline MESH: Ataxia Telangiectasia
Document information provided by NCBI PubMed

Text Mining Data

Dashed line = No text mining data

Manually curated Databases

IRef Hprd Interaction: CHEK1 — ATM (in vivo)
IRef Hprd Interaction: CHEK1 — ATM (in vitro)
IRef Hprd Interaction: CHEK1 — ATR (in vitro)
IRef Hprd Interaction: CHEK1 — ATR (in vivo)
IRef Hprd Interaction: WRN — ATM (in vitro)
IRef Hprd Interaction: NBN — ATM (in vivo)
IRef Hprd Interaction: NBN — ATM (in vitro)

In total, 4 gene pairs are associated to this article in curated databases