J Exp Med 2005,
PMID: 16216886
Annacker, Oliver; Coombes, Janine L; Malmstrom, Vivianne; Uhlig, Holm H; Bourne, Tim; Johansson-Lindbom, Bengt; Agace, William W; Parker, Christina M; Powrie, Fiona
The integrin CD103 is highly expressed at mucosal sites, but its role in mucosal immune regulation remains poorly understood. We have analyzed the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis. Our results show no mandatory role for CD103 expression on T cells for either the development or CD4+CD25+ regulatory T (T reg) cell-mediated control of colitis. However, wild-type CD4+CD25+ T cells were unable to prevent colitis in immune-deficient recipients lacking CD103, demonstrating a nonredundant functional role for CD103 on host cells in T reg cell-mediated intestinal immune regulation. Non-T cell expression of CD103 is restricted primarily to CD11c(high)MHC class II(high) dendritic cells (DCs). This DC population is present at a high frequency in the gut-associated lymphoid tissue and appears to mediate a distinct functional role. Thus, CD103+ DCs, but not their CD103- counterparts, promoted expression of the gut-homing receptor CCR9 on T cells. Conversely, CD103- DCs promoted the differentiation of IFN-gamma-producing T cells. Collectively, these data suggest that CD103+ and CD103- DCs represent functionally distinct subsets and that CD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine.
Diseases/Pathways annotated by Medline MESH: Colitis
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Text Mining Data
CCR9 → DCs: "
Thus, CD103+
DCs , but not their CD103- counterparts,
promoted expression of the gut homing receptor
CCR9 on T cells
"
Manually curated Databases
No curated data.