Gene interactions and pathways from curated databases and text-mining
J Biol Chem 2007, PMID: 17220297

Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling.

Zhao, Yongge; Conze, Dietrich B; Hanover, John A; Ashwell, Jonathan D

TRAF2 and ASK1 play essential roles in tumor necrosis factor alpha (TNF-alpha)-induced mitogen-activated protein kinase signaling. Stimulation through TNF receptor 2 (TNFR2) leads to TRAF2 ubiquitination and subsequent proteasomal degradation. Here we show that TNFR2 signaling also leads to selective ASK1 ubiquitination and degradation in proteasomes. c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and studies with primary B cells from c-IAP1 knock-out animals revealed that c-IAP1 is required for TNFR2-induced TRAF2 and ASK1 degradation. Moreover, in the absence of c-IAP1 TNFR2-mediated p38 and JNK activation was prolonged. Thus, the ubiquitin protein ligase activity of c-IAP1 is responsible for regulating the duration of TNF signaling in primary cells expressing TNFR2.

Diseases/Pathways annotated by Medline MESH: MAP Kinase Signaling System
Document information provided by NCBI PubMed

Text Mining Data

mitogen activated protein kinase → tumor necrosis factor alpha (TNF-alpha): " TRAF2 and ASK1 play essential roles in tumor necrosis factor alpha (TNF-alpha) induced mitogen activated protein kinase signaling "

mitogen activated protein kinase — TRAF2: " TRAF2 and ASK1 play essential roles in tumor necrosis factor alpha (TNF-alpha) induced mitogen activated protein kinase signaling "

mitogen activated protein kinase — ASK1: " TRAF2 and ASK1 play essential roles in tumor necrosis factor alpha (TNF-alpha) induced mitogen activated protein kinase signaling "

TRAF2 → TNF receptor 2 (TNFR2): " Stimulation through TNF receptor 2 (TNFR2) leads to TRAF2 ubiquitination and subsequent proteasomal degradation "

ASK1 → TNFR2: " Here we show that TNFR2 signaling also leads to selective ASK1 ubiquitination and degradation in proteasomes "

TRAF2 → TNFR2: " c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and studies with primary B cells from c-IAP1 knock-out animals revealed that c-IAP1 is required for TNFR2 induced TRAF2 and ASK1 degradation "

TRAF2 → c-IAP1: " c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and studies with primary B cells from c-IAP1 knock-out animals revealed that c-IAP1 is required for TNFR2 induced TRAF2 and ASK1 degradation "

ASK1 → TNFR2: " c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and studies with primary B cells from c-IAP1 knock-out animals revealed that c-IAP1 is required for TNFR2 induced TRAF2 and ASK1 degradation "

ASK1 → c-IAP1: " c-IAP1 was identified as the ubiquitin protein ligase for ASK1 ubiquitination, and studies with primary B cells from c-IAP1 knock-out animals revealed that c-IAP1 is required for TNFR2 induced TRAF2 and ASK1 degradation "

Manually curated Databases

  • IRef Innatedb Interaction: MAP3K5 — BIRC2 (unknown, -)
In total, 1 gene pairs are associated to this article in curated databases