Int Rev Immunol 2008,
PMID: 18853341
Sarkar, Fazlul H; Li, Yiwei; Wang, Zhiwei; Kong, Dejuan
The nuclear factor-kappaB (NF-kappaB) pathway is one of the most important cellular signal transduction pathways involved in both physiologic processes and disease conditions. It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers. More importantly, recent studies have shown that NF-kappaB signaling also plays critical roles in the epithelial-mesenchymal transition (EMT) and cancer stem cells. Therefore, targeting of NF-kappaB signaling pathway could be a potent strategy for the prevention and/or treatment of human cancers and inflammatory diseases.
Diseases/Pathways annotated by Medline MESH: Cell Transformation, Neoplastic, Inflammation, Metabolic Diseases, Neoplasms
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epithelial-mesenchymal transition (EMT) — NF-kappaB: "
More importantly, recent studies have shown that
NF-kappaB signaling also
plays critical roles in the
epithelial-mesenchymal transition (EMT) and cancer stem cells
"
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