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DVL2 — WNT2
Text-mined interactions from Literome
Strovel et al., J Biol Chem 2000
:
PP2C exists in a complex with
Dvl , beta-catenin, and Axin, a negative
regulator of
Wnt signaling
Habas et al., Cell 2001
:
Wnt/Fz activation of Rho
requires the cytoplasmic protein
Dishevelled ( Dvl ) and a novel Formin homology protein Daam1 ... Daam1 binds to both Dvl and Rho, and mediates
Wnt induced
Dvl-Rho complex formation
Shiomi et al., Curr Biol 2003
(Eye Abnormalities) :
In the canonical pathway,
Wnt receptors
activate Dishevelled ( Dvl ) , which then blocks the degradation of a key signal transducer, beta-catenin, leading to the nuclear accumulation of beta-catenin and induction of Wnt target genes through TCF/LEF family transcription factors
Habas et al., Genes Dev 2003
:
Dishevelled ( Dvl ), a cytoplasmic protein downstream of Fz, forms a Wnt induced complex with Rac independent of the
Wnt induced
Dvl-Rho complex
González-Sancho et al., Mol Cell Biol 2004
:
Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that
Dvl phosphorylation is not
sufficient to activate canonical
Wnt/beta-catenin signaling ... We conclude that
Wnt induced phosphorylation of
Dvl is independent of LRP5/6 receptors and that canonical Wnts can elicit both LRP dependent ( to beta-catenin ) and LRP independent ( to Dvl ) signals
Bryja et al., Proc Natl Acad Sci U S A 2007
:
Inhibition of
Wnt signaling by CK1 inhibitors
reduced the binding of beta-arrestin to
Dvl
Gan et al., J Cell Biol 2008
:
Disrupting the interaction of Dvl with either c-Jun or beta-catenin suppresses canonical
Wnt signaling stimulated transcription, and the reduction of
Dvl diminished beta-catenin-TCF-4 association on Wnt target gene promoters in vivo
Etheridge et al., PLoS Genet 2008
(Heart Defects, Congenital...) :
Interestingly, global canonical Wnt signaling appeared largely unaffected in the double Dvl mutants, suggesting that low
Dvl levels are
sufficient for functional canonical
Wnt signals
Gao et al., Cell Signal 2010
:
In addition,
Dvl plays important roles in
Wnt-GSK3beta-microtubule signaling, Wnt-calcium signaling, Wnt-RYK signaling, Wnt-atypical PKC signaling, etc
Sousa et al., J Biol Chem 2010
:
We found that purified
Wnt2 induces the phosphorylation of both Lrp5/6 and
Dvl-2/3 , and activates beta-catenin in SN4741 dopaminergic cells
Gao et al., Nat Cell Biol 2010
(Colonic Neoplasms) :
Here we show that autophagy negatively
regulates Wnt signalling by promoting
Dishevelled ( Dvl ) degradation
Perez et al., J Cell Biol 2011
(Neointima) :
Interfering with the
Dvl dependent
Wnt-PCP activation in a murine stented aortic graft injury model promotes extensive neointima formation, as shown by optical coherence tomography and histopathology
Sharma et al., J Biol Chem 2012
(Lafora Disease...) :
Overexpression of malin enhances the degradation of
dishevelled2 and
inhibits Wnt signaling, which is evident from the down-regulation of ß-catenin target genes and the decrease in ß-catenin mediated transcriptional activity
Wei et al., Mol Cell Biol 2012
(Wnt Signaling Pathway) :
ITCH ubiquitinates the phosphorylated form of
Dvl and promotes its degradation via the proteasome pathway, thereby
inhibiting canonical
Wnt signaling ... Consistently, overexpression of ITCH
inhibited wild-type
Dvl2 induced, but not Dvl2-Y568F mutant induced,
Wnt reporter activity
Barry et al., Nature 2013
(Colorectal Neoplasms...) :
DVL signals in the nucleus of intestinal stem cells, and its forced expression
leads to enhanced
Wnt signalling in crypts
González-Sancho et al., J Biol Chem 2013
:
Functional Consequences of
Wnt induced
Dishevelled 2 Phosphorylation in Canonical and Noncanonical Wnt Signaling
Ding et al., J Biol Chem 2013
(Wnt Signaling Pathway) :
Consistent with the
role of
Dvl in both
Wnt/ß-catenin and Wnt/planar cell polarity signaling, NEDD4L regulates the cellular ß-catenin level and Rac1, RhoA, and JNK activities
Goto et al., PloS one 2013
:
In Xenopus embryos, depletion of IQGAP1 reduced
Wnt induced nuclear accumulation of
DVL , and expression of Wnt target genes during early embryogenesis
Brigelius-Flohé et al., Methods Enzymol 2013
:
NOX1 derived H2O2 oxidizes Nrx leading to the liberation of
Dvl and the
activation of
Wnt signaling