Schreiner et al., Glia 2003
(Brain Neoplasms...) :
Inducible costimulator-ligand (ICOSL) , a member of the B7 family of costimulatory molecules related to CD80/CD86, regulates CD4 as well as CD8 T-cell responses via interaction with its receptor, ICOS, on activated T cells
Klingenberg et al., Eur J Immunol 2005
(Acute Disease) :
ICOSL blockade reduced CD8 ( + ) T cell proliferation by 70 % along with a marked decrease of IL-2 and IFN-gamma production in co-cultures with HUVEC ... Our data indicate a distinct role for ICOSL in EC-mediated CD8 ( + ) T cell costimulation with implications for human cardiac allograft rejection