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IFNA4 — IRF1
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Rubinstein et al., Antiviral Res 2000
:
While interferon alpha A was more sensitive than interferon tau to the inhibitory effects of the IRF-2 DBD,
IRF mediated gene induction is
involved in successful
interferon alpha and tau induced anti-VSV activity
Zhou et al., Ann Oncol 2000
(Carcinoid Tumor) :
The
interferon-alpha regulation of
interferon regulatory factor 1 (IRF-1) and IRF-2 has therapeutic implications in carcinoid tumors
Barnes et al., J Biol Chem 2001
:
Virus-specific activation of a novel
interferon regulatory factor , IRF-5,
results in the induction of distinct
interferon alpha genes
Lin et al., Oncogene 2001
:
vIRF-1 has been shown to downregulate the interferon- and
IRF mediated transcriptional
activation of ISG and murine
IFNA4 gene promoters
Hahn et al., J Virol 2005
(Leukoplakia, Hairy) :
However,
IRF-7 dependent activity of the
IFN-alpha4 , IFN-beta, and Tap-2 promoters, as well as an ISRE promoter construct, was inhibited by BZLF-1
Au et al., Nucleic Acids Res 1992
(Newcastle Disease) :
In the present study, we have shown that the
interferon regulatory factor 1 (IRF-1) can
induce expression of both
IFN-alpha 4 and -alpha 6 in a transient expression assay
Hochhaus et al., Leukemia 1997
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
Expression of
interferon regulatory factor ( IRF ) genes and
response to
interferon-alpha in chronic myeloid leukaemia
Schafer et al., J Biol Chem 1998
:
Surprisingly,
activation of the
IFNA4 gene promoter by virus and
IRF-1 in these cells was inhibited by IRF-3