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MST1R — SLC22A3

Text-mined interactions from Literome

Wang et al., Oncogene 2004 : In the study of signaling pathways responsible for RON mediated EMT , it was found that PD98059, a MAP kinase inhibitor, blocks the collaborative activities of RON and TGF-beta1 in induction of alpha-SMA expression and restores epithelial cells to their original morphology
Camp et al., Cancer 2007 (Neoplasm Invasiveness...) : It was hypothesized that RON , a tyrosine kinase receptor related to c-MET, would be expressed in human pancreatic cancer cells, induce EMT , and would thus serve as a target for therapy in a preclinical model
Côté et al., Biochem Biophys Res Commun 2007 : This study reveals for the first time that RON alone is sufficient to induce complete and stabilized EMT in MDCK cells, and overexpression of RON does not cause cell transformation but rather induces cell cycle arrest and senescence, leading to impaired cell proliferation