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OPN1MW — TNF

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Liou et al., Invest Ophthalmol Vis Sci 2008 : When the cells or rats were treated with LPS, activation of the A ( 2A ) AR was the most efficient in mediating AR agonist- or CBD induced TNF-alpha inhibition
Magen et al., J Hepatol 2009 (Chronic Disease...) : The effects of CBD on cognition, locomotion and on TNF-alpha receptor 1 expression were blocked by ZM241385, an A ( 2 ) A adenosine receptor antagonist
LIU et al., Acta Pharmacol Sin 2010 (Hypersensitivity, Delayed) : Histological examination revealed that CBD suppressed the infiltration of T cells and macrophages, and the expression of interferon ( IFN ) -? and tumor necrosis factor-a , two pro-inflammatory cytokines implicated in DTH in the inflammatory site
Mukhopadhyay et al., Free Radic Biol Med 2011 (Disease Models, Animal...) : CBD significantly reduced the extent of liver inflammation, oxidative/nitrative stress, and cell death and also attenuated the bacterial endotoxin triggered NF-?B activation and TNF-a production in isolated Kupffer cells, likewise the adhesion molecule expression in primary human liver sinusoidal endothelial cells stimulated with TNF-a and attachment of human neutrophils to the activated endothelium
Karmaus et al., J Immunotoxicol 2013 (Multiple Sclerosis...) : Concomitantly, CBD enhanced pro-inflammatory cytokine mRNA production, including tumor necrosis factor-a (Tnfa) , interleukins (IL)-5 and -23 ( Il6, Il23 ), and granulocyte colony stimulating factor ( Gcsf )