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FGB — SYK

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGB → SYK (reaction) Kurosaki et al., J Exp Med 1994, Gao et al., EMBO J 1997
• Reactome Reaction: FGB → SYK (indirect_complex) Kurosaki et al., J Exp Med 1994, Gao et al., EMBO J 1997

Text-mined interactions from Literome

Wonerow et al., Biochem J 2002 : In sharp contrast, although fibrinogen binding to platelets stimulates alphaIIbbeta3 dependent activation of Syk and tyrosine phosphorylation of SLP-76 and PLCgamma2, it does not utilize GEMs to promote these responses or to support platelet aggregation
Gao et al., EMBO J 1997 : Firstly, unlike alpha IIb beta 3-mediated activation of pp125FAK, Syk activation could be triggered by the binding of soluble fibrinogen and abolished by truncation of the alpha IIb or beta 3 cytoplasmic tail, and it was resistant to inhibition by cytochalasin D. Secondly, it did not require phosphorylated ITAMs since it was unaffected by disruption of an ITAM-interaction motif in the SH2 ( C ) domain of Syk or by simultaneous overexpression of the tandem SH2 domains