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FOS — MAP2K2

Pathways - manually collected, often from reviews:

• WikiPathways T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection: Complex of MAP2K2-MAP2K1 → Complex of JUN-FOS (activation)

Text-mined interactions from Literome

Manna et al., Oncogene 1999 : gamma-GCS also abolished the activation of AP-1 induced by TNF and inhibited TNF induced activation of JNK and mitogen activated protein kinase kinase
Manna et al., J Immunol 2000 : Vesnarinone also blocked NF-kappa B activation induced by several other inflammatory agents, inhibited the TNF induced activation of transcription factor AP-1 , and suppressed the TNF induced activation of c-Jun N-terminal kinase and mitogen activated protein kinase kinase
Ryborg et al., Acta Derm Venereol 2004 : The effects on transglutaminase-1 and AP-1 were dependent on protein kinase C and mitogen activated protein kinase kinase
Wang et al., Planta Med 2007 (Leukemia...) : Deerberry fruit extracts also blocked TPA- or UVB induced phosphorylation of ERKs and MEK 1/2 , two upstream regulators of AP-1 and inhibited proliferation of human leukemia HL-60 cancer cells and human lung epithelial cancer A549 cells and induced apoptosis of HL-60 cells