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FOS — PLAU

Pathways - manually collected, often from reviews:

• NCI Pathway Database Osteopontin-mediated events: AP1 complex (FOS-JUN) → uPA (PLAU) (transcription, activates) Mi et al., Carcinogenesis 2006
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database AP-1 transcription factor network: JUN/JUN-FOS/RACO-1 complex (JUN-FOS_JUN) → uPA (PLAU) (transcription, activates) Davies et al., Nat Cell Biol 2010
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS complex (FOS-JUN) → uPA (PLAU) (transcription, activates) D'Orazio et al., Gene 1997*
  Evidence: reporter gene
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS/GR/TRIP6/cortisol/GR alpha (dimer) complex (FOS-JUN-TRIP6-NR3C1) → uPA (PLAU) (transcription, inhibits) Diefenbacher et al., Mol Endocrinol 2008, Miralles et al., Mol Cell Biol 1998
  Evidence: reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUN/FOS/TRIP6 complex (FOS-JUN-TRIP6) → uPA (PLAU) (transcription, activates) Diefenbacher et al., Mol Endocrinol 2008, Miralles et al., Mol Cell Biol 1998
  Evidence: reporter gene, physical interaction
• NCI Pathway Database AP-1 transcription factor network: JUND/FOS complex (JUND-FOS) → uPA (PLAU) (transcription, activates) D'Orazio et al., Gene 1997*
  Evidence: reporter gene, physical interaction
• NCI Pathway Database ATF-2 transcription factor network: JUN/FOS complex (FOS-JUN) → uPA (PLAU) (transcription, inhibits) Cirillo et al., Mol Cell Biol 1999*, De Cesare et al., Oncogene 1995*, D'Orazio et al., Gene 1997*
  Evidence: reporter gene, physical interaction

Text-mined interactions from Literome

Das et al., J Biol Chem 2004 (Breast Neoplasms...) : However, the role ( s ) of OPN on AP-1 mediated uPA secretion and cell motility and the involvement of c-Src/epidermal growth factor receptor (EGFR) in these processes in breast cancer cells are not well defined ... To our knowledge, this is the first report that OPN induces alpha(v)beta(3) integrin mediated AP-1 activity and uPA secretion by activating c-Src/EGFR/ERK signaling pathways and further demonstrates a functional molecular link between OPN induced integrin/c-Src dependent EGFR phosphorylation and ERK/AP-1 mediated uPA secretion, and all of these ultimately control the motility of breast cancer cells
Huang et al., J Cell Physiol 2012 (Colorectal Neoplasms...) : Inhibition of Sp1 and AP-1 activation blocked the SDF-1 induced expression and activity of the uPA promoter
Lee et al., J Biol Chem 1994 : DNA-protein interaction studies, together with mRNA and protein analyses, indicate that c-Jun, but not c-Fos , is involved in OA-dependent uPA gene induction
Dear et al., FEBS Lett 1997 (Fibrosarcoma...) : Since transcription factors bound to AP-1 recognition sequences within the PAI-2 gene promoter play a role in basal and phorbol ester mediated induction of PAI-2 gene expression, we hypothesised that u-PA/u-PAR mediated modulation of AP-1 activity would in turn influence constitutive and inducible PAI-2 gene expression