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IL2RA — TLR4

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Han et al., Infect Immun 2003 : The target cells used in the study were peripheral blood mononuclear cells ( PBMCs ) and two model cell lines ( CHO/CD14/TLR2 and CHO/CD14/TLR4 ) that express human CD25 protein in response to Toll-like receptor 2 (TLR2) and TLR4 stimulation, respectively
Maxwell et al., J Immunol 2004 : TLR stimulation induced an increase in CD25 expression, acquisition of surface MHC class II, and abnormally high increases in forward and side scatter of the peptide-specific T cells
Farina et al., Int Immunol 2004 : Both TLR-ligands and inflammatory cytokines induced the expression of CD25 , CD69, CD80 and, surprisingly, also of CD83, commonly regarded as an activation marker for mature dendritic cells ( DC )
Brisslert et al., Immunology 2006 : CD25 expression on B cells was selectively up-regulated by Toll-like receptor 2 (TLR2), TLR4 , and TLR9 ligands but not by a TLR3 ligand or Epstein-Barr virus ( EBV ) stimulation
Zhai et al., J Immunol 2006 : TLR4 signaling has been implicated in the regulation of CD4 ( + ) CD25 ( + ) Treg functions recently
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed