Gene interactions and pathways from curated databases and text-mining

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EPHB2 — IL2RA

Text-mined interactions from Literome

Lüschen et al., Biochem Biophys Res Commun 2000 : Activation of ERK1/2 and cPLA(2) by the p55 TNF receptor occurs independently of FAN
Ben-David et al., Scand J Immunol 2007 (Disease Models, Animal...) : Moreover, inhibition of ERK1,2 in the dual APL induced regulatory CD4 ( + ) CD25 ( + ) cells, resulted in downregulation of the forkhead box p3 (Foxp3) gene and protein expression levels, as well as in the downregulation of CD4 ( + ) CD25 ( + ) development, suggesting that the active suppression exerted by the dual APL via CD4 ( + ) CD25 ( + ) cells depends on ERK1,2 activity
Conrad et al., Cell Signal 2009 : Inhibition of JNK, but not ERK1/2 or p38 MAPK, caused a marked reduction in Thy-1 induced CD25 expression ... In addition, inhibition of p38 MAPK or JNK, but not ERK1/2 , impaired the growth of IL-2 dependent CTLL-2 T-lymphocytes but did not substantially affect CD25 expression
Zhao et al., BioMed research international 2013 (MAP Kinase Signaling System) : Either using PD98059 ( a specific inhibitor for p-ERK ) or depletion of ERK with small interfering RNA ( siRNA ) reduced the expression of CD25