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EPHB2 — SMAD7

Text-mined interactions from Literome

Uchida et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : These results indicated that ERK activation negatively regulated Smad7 transcription possibly by inhibiting translocation of Smad complex to nuclei
Leask et al., J Biol Chem 2003 : Now we show that protein kinase C and Ras/MEK/ERK are necessary for the TGF-beta induction of the CTGF promoter but not of a generic Smad-responsive promoter ( SBE-lux )
Kfir et al., Mol Cell Biol 2005 : Pathway- and expression level dependent effects of oncogenic N-Ras : p27 ( Kip1 ) mislocalization by the Ral-GEF pathway and Erk mediated interference with Smad signaling
Wang et al., Circ Res 2006 (Arteriosclerosis...) : This was extracellular signal regulated kinase 1/2 ( ERK1/2 ) mitogen activated protein kinase ( MAPK ) dependent but transforming growth factor-beta ( TGF-beta ) independent because Ang II-induced Smad signaling was blocked by addition of ERK1/2 inhibitor and by dominant negative ( DN ) ERK1/2 but not by DN-TGF-beta receptor II (TbetaRII) or conditional deletion of TbetaRII
Huo et al., Cell Biol Toxicol 2007 (MAP Kinase Signaling System) : Our results demonstrate that TGF-beta1 activates ERK in a time dependent manner with a maximum effect at 60 min ; overexpression of Smad7 increased this TGF-beta1 mediated phosphorylation of the ERK ; and siRNA mediated silencing of TbetaRII, Smad3, Smad4, and Smad7 abrogated this effect ... Moreover, we observed that overexpression of Smad7 restored TGF-beta1 mediated ERK phosphorylation in Smad4 knockdown cells but not in TbetaRII knockdown cells ... These data revealed that TbetaRII and Smad7 play the critical roles in TGF-beta1 mediated activation of ERK ; Smad3 and Smad4 can play an indirect role through up-regulating Smad7 expression ; and TGF-beta1 induced phosphorylation of ERK may participate in BEP2D cell proliferation and apoptosis regulation
Zhou et al., J Allergy Clin Immunol 2007 (Asthma...) : These increases occur as TGF-beta1 downregulates IL-13 induced phosphoinositide-3 kinase activation while leaving the positive effect of IL-13 induced ERK on Smad signaling
An et al., American journal of physiology. Renal physiology 2009 (Fibrosis...) : The untreated CRF rats exhibited proteinuria, hypertension, azotemia, upregulations of renal tissue NAD ( P ) H oxidase, MCP-1, COX-2, PAI-1, TGF-beta, Smad2, alpha-smooth muscle actin, fibronectin, and hepatocyte growth factor, activation of ERK1/2 and NF-kappaB, downregulation of Smad7 , intense mononuclear leukocyte infiltration, tubulointerstitial fibrosis, and glomerulosclerosis
Heger et al., J Cell Physiol 2010 (Cardiomegaly...) : Specific inhibitors of PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also blocked GDF15 induced hypertrophy and SMAD activation