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EPHB2 — TIE1
Text-mined interactions from Literome
Yoon et al., Biochem Biophys Res Commun 2003
:
Localization of
Tie2 and phospholipase D in endothelial caveolae is
involved in angiopoietin-1 induced
MEK/ERK phosphorylation and migration in endothelial cells
Tai et al., J Biol Chem 2005
:
Tie2 and PECAM1 expression decreased > 80 % after siRNA treatment, and flow stimulated phosphorylation of
ERK1/2 , Akt, and endothelial nitric oxide synthase was significantly
inhibited by Tie2 and PECAM1 siRNA
Fukuhara et al., Nat Cell Biol 2008
:
Furthermore,
Tie2 activated at cell-cell or cell-substratum contacts
leads to preferential activation of Akt and
Erk , respectively
Yamakawa et al., J Biol Chem 2013
:
When activation of Tie2YIA/LAS was induced by a high dose of Ang1, phosphorylation of Tie2 was limited compared with wild-type Tie2, resulting in retardation of
activation of
Erk downstream of
Tie2