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HIF1A — TLR4

Text-mined interactions from Literome

Nicholas et al., Immunol Cell Biol 2010 : RNS and p38 MAP kinase ( known to contribute to LPS induced TLR4 dependent accumulation of HIF-1 alpha protein ) do not affect HIF-1 alpha prolyl hydroxylation
Kim et al., Immunology 2010 (Anoxia) : Knockdown of HIF-1alpha expression by small interfering RNA inhibited hypoxia induced and CoCl ( 2 ) -induced TLR4 expression in macrophages, while over-expression of HIF-1alpha potentiated TLR4 expression ... In addition, deletion or mutation of a putative HIF-1 binding motif in the TLR4 promoter greatly attenuated HIF-1alpha induced TLR4 promoter reporter expression
Spirig et al., PloS one 2010 : In this study, we show that exogenous as well as endogenous inflammatory stimuli for TLR4 and TLR2 induce the expression of HIF-1alpha in human monocyte derived DC under normoxic conditions ... In addition, we could show that TLR stimulation resulted in an increase of HIF-1alpha controlled VEGF secretion