Gene interactions and pathways from curated databases and text-mining

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BAG3 — MCL1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Jacobs et al., J Biol Chem 2009 : Silencing BAG3 expression with small interfering RNA caused a dramatic reduction in Bcl-X ( L ), Mcl-1 , and Bcl-2 protein levels in colon cancer cells and increased apoptosis, similar to the effect of silencing HSF1
Boiani et al., J Biol Chem 2013 (Neoplasms) : RNA silencing of BAG3 led to a marked reduction in Mcl-1 protein levels and overcame ABT-737 resistance in Mcl-1 dependent cells