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MCL1 — USP9X

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: USP9X — MCL1 (direct interaction, enzymatic study) Trivigno et al., Neoplasia (New York, N.Y.) 2012*
• IRef Biogrid Interaction: USP9X — MCL1 (physical association, affinity chromatography technology) Peddaboina et al., BMC cancer 2012*
• IRef Biogrid Interaction: USP9X — MCL1 (physical association, affinity chromatography technology) Gomez-Bougie et al., Biochem Biophys Res Commun 2011*
• IRef Biogrid Interaction: USP9X — MCL1 (direct interaction, enzymatic study) Schwickart et al., Nature 2010*
• IRef Biogrid Interaction: USP9X — MCL1 (physical association, affinity chromatography technology) Schwickart et al., Nature 2010*
• IRef Biogrid Interaction: USP9X — MCL1 (physical association, affinity chromatography technology) Zhang et al., Mol Cancer Ther 2011*
• IRef Dip Interaction: Complex of 16 proteins (anti bait coimmunoprecipitation) Schwickart et al., Nature 2010*
• IRef Dip Interaction: USP9X — MCL1 (direct interaction, anti bait coimmunoprecipitation) Schwickart et al., Nature 2010*
• IRef Dip Interaction: USP9X — MCL1 (direct interaction, anti tag coimmunoprecipitation) Schwickart et al., Nature 2010*
• IRef Dip Interaction: USP9X — MCL1 (direct interaction, enzymatic study) Schwickart et al., Nature 2010*
• IRef Dip Interaction: Complex of MCL1-BAK1-USP9X (anti bait coimmunoprecipitation) Schwickart et al., Nature 2010*

Text-mined interactions from Literome

Schwickart et al., Nature 2010 (Neoplasms) : Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival ... Here we show that the deubiquitinase USP9X stabilizes MCL1 and thereby promotes cell survival
Trivigno et al., Neoplasia (New York, N.Y.) 2012 : In addition, the overexpression of the deubiquitinase ubiquitin-specific protease 9x (USP9x) can result in the accumulation of Mcl-1 by removing poly-ubiquitin chains from Mcl-1 preventing its proteasomal degradation ... Together, our results indicate that radiation induced activation of USP9x inhibits Mcl-1 degradation and apoptosis resulting in increased radioresistance
Weber et al., Apoptosis 2013 : The Noxa dependent degradation of Mcl-1 was independent of the kinase GSK3 and the deubiquitinase Usp9x in mouse embryonic fibroblasts