Gene interactions and pathways from curated databases and text-mining

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IGF1 — ITGB1

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: ITGB1 → IGF1 (increases)
    Evidence: Treatment of HT29-D4 cells with antibodies to alphaV, alpha-6 and beta-1 integrins significantly inhibited the des (1-3)-IGF1 (analogue of IGF-1) induced cell migration. Incubation with a mixture containing anti-alphaV, anti-alpha6 and anti-beta1antibodies together totally abolished migration, indicating that these integrin subunits are involved in the IGF-1 induced cell migration.

Text-mined interactions from Literome

Barazi et al., Cancer Res 2002 : Furthermore, mizoribine, an HSP60 binding drug, blocked activation of the alpha 3 beta 1 integrin induced by insulin-like growth factor 1 (IGF1) or exogenous recombinant HSP60 and inhibited the association of HSP60 with the integrin ... Additionally, inhibiting the surface expression of endogenous HSP60 by nonactin inhibited activation of the alpha 3 beta 1 integrin by IGF1
Chang et al., American journal of stem cells 2012 : Furthermore, 5 µg IGF-1 also resulted in the highest number of putative CD49f ( + ) CD24 ( + ) and CD49f ( + ) CD24 ( + ) CD29 ( + ) breast stem/progenitor cells in the wild type offspring when compared to PBS controls, as assessed by flow cytometric analysis of dissociated cells from the right fourth inguinal mammary gland, while significantly higher numbers of these cell populations as well as CD24 ( + ) CD29 ( + ) and CD49f ( + ) EpCAM ( + ) cells were observed in IGF-1 deficient mice
Doerr et al., J Biol Chem 1996 (Breast Neoplasms) : We conclude that : 1 ) IGF-I stimulates migration of these two cell types through the IGF-I receptor ; 2 ) interaction of vitronectin with the alpha v beta 5 integrin or collagen with the alpha 2 beta 1 integrin is necessary for the complete IGF-I response in MCF-7 cells, and 3 ) because migration represents an in vitro model for metastatic spread, integrins, extracellular matrix proteins, and IGF-I may play coordinated roles in the metastasis of breast cancer in vivo
Galiano et al., J Clin Invest 1996 (Skin Ulcer) : Our results suggest that activation of both the IGF-I receptor and the alpha5beta1 integrin is required for IGF-I to stimulate wound healing
Loeser et al., Arthritis Rheum 1997 : Differential effects of insulin-like growth factor 1 and transforming growth factor beta on alpha 1 beta 1 integrin expression and chondrocyte adhesion to type VI collagen