Gene interactions and pathways from curated databases and text-mining

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DUSP1 — EGR1

Text-mined interactions from Literome

Stefano et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Lentiviral mediated expression of MAP kinase phosphatase-1 (MKP-1) , a dual-specific phosphatase that dephosphorylates and inactivates ERK in the nucleus, inhibited Egr-1 biosynthesis following BzATP stimulation, indicating that MKP-1 functions as a nuclear shut-off device
Mayer et al., J Cell Biochem 2008 : Elk-1, CREB, and MKP-1 regulate Egr-1 expression in gonadotropin releasing hormone stimulated gonadotrophs
Horita et al., J Comp Neurol 2010 : Dusp1 is an inactivator of mitogen activated protein kinase ( MAPK ), and MAPK activates expression of egr1 , one of the most commonly studied IEGs, as determined in cultured cells