Gene interactions and pathways from curated databases and text-mining

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HPD — IL6

Text-mined interactions from Literome

Wagner et al., Med Microbiol Immunol 2013 : PPD and LPS significantly increased IL-6 , IL-10, and TNF-a production in PBMCs. IL-10 and TNF-a production were significantly lower in a subgroup of CD patients ( 5/12 ) with a known NOD2 mutation
Link et al., J Neuroimmunol 1995 (Inflammation...) : Femtogram concentrations of rTGF-beta 1 suppressed MBP-, PLP- and PPD induced upregulation of IFN-gamma, IL-4, IL-6 , tumor necrosis factor-alpha (TNF-alpha), TNF-beta and perforin in MS, and acetylcholine receptor ( AChR ) -induced augmentation of these pro-inflammatory cytokines in MG, but had no effects on autoantigen- or PPD induced expression of IL-10 or TGF-beta itself
Zembala et al., Immunol Invest 1994 : Parallel changes were observed in PPD induced IL-6 production