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PERP — TP53
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
TP53
—
PERP
(interaction, mapped from intact)
-
STRING interaction:
PERP
—
TP53
(interaction, mapped from intact)
Text-mined interactions from Literome
Attardi et al., Genes Dev 2000
:
Here, we describe the characterization of a gene identified in this screen,
PERP , which is expressed in a
p53 dependent manner and at high levels in apoptotic cells compared with G ( 1 ) -arrested cells ... Furthermore, analysis of the PERP promoter suggests that
PERP is directly
activated by
p53
Chao et al., EMBO J 2000
:
p53 ( Gln25Ser26 ) was stable but did not accumulate after DNA damage ; the expression of p21/Waf1 and
PERP was not
induced , and p53 dependent repression of MAP4 expression was abolished
Ihrie et al., Curr Biol 2003
:
Thus,
Perp selectively
mediates the
p53 apoptotic response, and the requirement for Perp is dictated by cellular context
Reczek et al., Mol Cancer Res 2003
:
Here, we describe the
regulation of the
Perp gene by
p53 through at least three response elements in the Perp promoter and first intron
Paraoan et al., Exp Eye Res 2006
(Melanoma...) :
Expression of
p53 induced apoptosis effector
PERP in primary uveal melanomas : downregulation is associated with aggressive type
Singaravelu et al., American journal of physiology. Renal physiology 2009
(Disease Models, Animal...) :
These data suggest that
PERP is a key effector of
p53 mediated apoptotic pathways and is a potential therapeutic target for renal IRI
Davies et al., Cell death & disease 2011
(Melanoma...) :
PERP expression
stabilizes active
p53 via modulation of p53-MDM2 interaction in uveal melanoma cells ... Using fluorescent fusion proteins of PERP, p53 and MDM2, we demonstrate in single living UM cells that
PERP expression significantly
enhances p53 activity and its nuclear localization, increases p53 dependent transcription ( including that of MDM2 ) while allowing oscillatory nucleo-cytoplasmic shuttling of p53/MDM2 complexes