◀ Back to IL1A
IL1A — IRAK4
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IRAK4 (IRAK4)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
IRAK4 (IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88 complex (IL1A-IL1R1-IL1RAP-MYD88)
(modification, collaborate)
Li et al., Proc Natl Acad Sci U S A 2002
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
TRAF6 (TRAF6)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
→
IRAK/TRAF6 complex (IRAK1-TRAF6)
(modification, collaborate)
Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IRAK/TOLLIP complex (IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
NCI Pathway Database IL1-mediated signaling events:
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
NCI Pathway Database IL1-mediated signaling events:
IRAK/TOLLIP complex (IRAK1-TOLLIP)
→
IL1 alpha/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1A-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP)
(modification, collaborate)
Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003
-
Reactome Reaction:
IL1A
→
IRAK4
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Burns et al., J Exp Med 2003, Kollewe et al., J Biol Chem 2004, Brikos et al., Mol Cell Proteomics 2007*, Gottipati et al., Cell Signal 2008
-
Reactome Reaction:
IL1A
→
IRAK4
(indirect_complex)
Burns et al., J Exp Med 2003, Cheng et al., Biochem Biophys Res Commun 2007, Brikos et al., Mol Cell Proteomics 2007*
Text-mined interactions from Literome
Knop et al., FEBS Lett 1999
:
Effects of
IL-1 receptor associated kinase (IRAK) expression on
IL-1 signaling are independent of its kinase activity
Li et al., Mol Cell Biol 1999
:
To address the
role of the kinase activity of
IRAK in
IL-1 signaling, its ATP binding site was mutated ( K239A ), completely abolishing kinase activity
Valter et al., Int J Dev Neurosci 1999
(Glioma...) :
This suggests that baseline secretion of VEGF involves
IL-1 receptor activation by endogenously produced
IL-1
Wan et al., Cell Signal 2001
:
However,
IL-1beta induced
IRAK activation was not affected by PD153035
La et al., J Immunol 2001
:
Transcriptional
regulation of intracellular
IL-1 receptor antagonist gene by
IL-1 alpha in primary mouse keratinocytes
Qian et al., J Biol Chem 2001
:
When
IRAK is phosphorylated in
response to
IL-1 , it binds to the membrane where it forms a complex with TRAF6 ; TRAF6 then dissociates and translocates to the cytosol
Li et al., Proc Natl Acad Sci U S A 2002
(MAP Kinase Signaling System) :
Endogenous
IRAK-4 interacts with IRAK-1 and TRAF6 in an
IL-1 dependent manner, and overexpression of IRAK-4 can activate NF-kappa B as well as mitogen activated protein ( MAP ) kinase pathways
Mamidipudi et al., J Biol Chem 2004
:
Moreover, transfection of kinase-dead iota PKC blocked both NGF- and
IL-1 induced
IRAK activation and the activity of NF-kappaB
Takeuchi et al., Clin Exp Immunol 1992
:
125I labelled
IL-1 alpha binding on PHA stimulated murine thymocytes revealed two types of IL-1 binding sites, 44 sites/cell with a Kd of 2.7 x 10 ( -10 ) M and 230 sites/cell with a Kd of 2.5 x 10 ( -9 ) M. Alveolar macrophage culture supernatants
blocked the binding of labelled IL-1 to the
IL-1 receptor in a dose dependent fashion
Medvedev et al., J Immunol 2005
(Bacterial Infections...) :
IL-1 induced a strong interaction among the IL-1R, activated IRAK-1, MyD88, and WT, but not mutant,
IRAK-4
Jurrmann et al., J Nutr 2005
(Thymoma...) :
An early event in inflammatory signaling cascades is the recruitment of the interleukin-1 (IL-1) receptor associated kinase ( IRAK ) to the
IL-1 receptor ( IL-1RI ) upon
stimulation with
IL-1
Carroll et al., J Immunol 2005
(Inflammation) :
In addition, the expression of dominant negative IRAK-1 ( IRAK-1delta ), IRAK-2delta, or
IRAK-4delta inhibited
IL-1- and NE-induced NF-kappaB linked reporter gene expression
Koziczak-Holbro et al., J Biol Chem 2007
(Inflammation) :
IRAK-4 kinase activity is
required for
interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression
Ku et al., J Exp Med 2007
(Bacterial Infections) :
The
IRAK-4 dependent TLRs and
IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae
Horuk et al., Biochem J 1991
:
This could have direct consequences for
IL-1 action and
IL-1 receptor regulation in the cell
Xiao et al., J Biol Chem 2008
:
Pellino 3b-mediated Lys-63 linked IRAK polyubiquitination competed with Lys-48 linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking
IL-1 induced
IRAK degradation ... Importantly, the negative impact of Pellino 3b on IL-1 induced IRAK degradation correlated with the inhibitory effect of Pellino 3b on the IL-1 induced TAK1 dependent pathway, suggesting that a positive
role of
IRAK degradation in
IL-1 induced TAK1 activation
Staschke et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
The
IL-1R associated kinase 4 (IRAK4) is
critical for
IL-1/TLR signaling ... The results of these studies demonstrate that
IL-1 mediated
IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease
Sujita et al., Biochem Biophys Res Commun 1990
:
Effect of
interleukin 1 (IL-1) on the levels of cytochrome P-450 involving
IL-1 receptor on the isolated hepatocytes of rat
Huang et al., J Neurosci 2011
:
IL-1 signaling
requires the type 1
IL-1 receptor and the IL-1 receptor accessory protein ( IL-1RAcP ) as a receptor partner
Lee et al., Exp Mol Med 2012
(Arthritis, Rheumatoid...) :
Adiponectin and
IL-1ß each
increased the expression of both adiponectin receptor 1 and
IL-1 receptor 1
Gallis et al., J Immunol 1989
:
IL-1 induces rapid phosphorylation of the
IL-1 receptor
Dubois et al., Exp Hematol 1993
:
Hematopoietic growth factors and glucocorticoids synergize to mimic the
effects of
IL-1 on granulocyte differentiation and
IL-1 receptor induction on bone marrow cells in vivo
Arora et al., J Biol Chem 1995
:
These studies therefore demonstrate that activation of intracellular signaling pathways by
IL-1 is
dependent on
IL-1 receptor-cytoskeletal protein interactions
Rédini et al., Arthritis Rheum 1993
:
TGF beta reduced both
IL-1 effects on matrix metabolism and
IL-1 receptor expression
Chandrasekhar et al., Agents Actions Suppl 1993
:
To determine whether the two processes are linked, we studied the influence of growth factors on
IL-1 induced neutral protease induction, proteoglycan synthesis inhibition and
IL-1 receptor expression
Tan et al., J Clin Endocrinol Metab 1996
(Eye Diseases...) :
Interleukin-1 (IL-1) receptor antagonist and soluble
IL-1 receptor inhibit
IL-1 induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves ' ophthalmopathy
Cao et al., Nature 1996
:
IL-1 treatment of 293 cells
induces the association of TRAF6 with
IRAK , a serine/threonine kinase that is rapidly recruited to the IL-1 receptor after IL-1 induction
Chizzolini et al., Eur J Immunol 1997
(Inflammation) :
Human Th1 cells preferentially
induce interleukin (IL)-1beta while Th2 cells induce
IL-1 receptor antagonist production upon cell/cell contact with monocytes
Wesche et al., J Biol Chem 1997
:
The interleukin-1 receptor accessory protein ( IL-1RAcP ) is essential for
IL-1 induced activation of interleukin-1 receptor associated kinase (
IRAK ) and stress activated protein kinases ( SAP kinases ) ... The expression of IL-1RAcP in EL-4 D6/76 was sufficient to restore
IL-1 induced activation of
interleukin-1 receptor associated kinase and of stress activated protein kinases, translocation of the transcription factors NFkappaB and IL-1 NF to the nucleus, and induction of IL-2 mRNA synthesis
Ando et al., Endocrinology 1998
:
The effects of
IL-1 proved relatively specific, contingent upon somatic cell-cell cooperation, dose and time dependent, and
IL-1 receptor mediated
Eriksson et al., Int J Mol Med 1998
:
Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of
IL-1alpha and IL-6 by betaA25-35, is
dependent on the
IL-1 receptor type I (IL-1RI) , the only known signalling IL-1 receptor