Gene interactions and pathways from curated databases and text-mining

◀ Back to IL1A

IL1A — IRAK4

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Knop et al., FEBS Lett 1999 : Effects of IL-1 receptor associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
Li et al., Mol Cell Biol 1999 : To address the role of the kinase activity of IRAK in IL-1 signaling, its ATP binding site was mutated ( K239A ), completely abolishing kinase activity
Valter et al., Int J Dev Neurosci 1999 (Glioma...) : This suggests that baseline secretion of VEGF involves IL-1 receptor activation by endogenously produced IL-1
Wan et al., Cell Signal 2001 : However, IL-1beta induced IRAK activation was not affected by PD153035
La et al., J Immunol 2001 : Transcriptional regulation of intracellular IL-1 receptor antagonist gene by IL-1 alpha in primary mouse keratinocytes
Qian et al., J Biol Chem 2001 : When IRAK is phosphorylated in response to IL-1 , it binds to the membrane where it forms a complex with TRAF6 ; TRAF6 then dissociates and translocates to the cytosol
Li et al., Proc Natl Acad Sci U S A 2002 (MAP Kinase Signaling System) : Endogenous IRAK-4 interacts with IRAK-1 and TRAF6 in an IL-1 dependent manner, and overexpression of IRAK-4 can activate NF-kappa B as well as mitogen activated protein ( MAP ) kinase pathways
Mamidipudi et al., J Biol Chem 2004 : Moreover, transfection of kinase-dead iota PKC blocked both NGF- and IL-1 induced IRAK activation and the activity of NF-kappaB
Takeuchi et al., Clin Exp Immunol 1992 : 125I labelled IL-1 alpha binding on PHA stimulated murine thymocytes revealed two types of IL-1 binding sites, 44 sites/cell with a Kd of 2.7 x 10 ( -10 ) M and 230 sites/cell with a Kd of 2.5 x 10 ( -9 ) M. Alveolar macrophage culture supernatants blocked the binding of labelled IL-1 to the IL-1 receptor in a dose dependent fashion
Medvedev et al., J Immunol 2005 (Bacterial Infections...) : IL-1 induced a strong interaction among the IL-1R, activated IRAK-1, MyD88, and WT, but not mutant, IRAK-4
Jurrmann et al., J Nutr 2005 (Thymoma...) : An early event in inflammatory signaling cascades is the recruitment of the interleukin-1 (IL-1) receptor associated kinase ( IRAK ) to the IL-1 receptor ( IL-1RI ) upon stimulation with IL-1
Carroll et al., J Immunol 2005 (Inflammation) : In addition, the expression of dominant negative IRAK-1 ( IRAK-1delta ), IRAK-2delta, or IRAK-4delta inhibited IL-1- and NE-induced NF-kappaB linked reporter gene expression
Koziczak-Holbro et al., J Biol Chem 2007 (Inflammation) : IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression
Ku et al., J Exp Med 2007 (Bacterial Infections) : The IRAK-4 dependent TLRs and IL-1Rs are therefore vital for childhood immunity to pyogenic bacteria, particularly Streptococcus pneumoniae
Horuk et al., Biochem J 1991 : This could have direct consequences for IL-1 action and IL-1 receptor regulation in the cell
Xiao et al., J Biol Chem 2008 : Pellino 3b-mediated Lys-63 linked IRAK polyubiquitination competed with Lys-48 linked IRAK polyubiquitination for the same ubiquitination site, Lys-134 of IRAK, thereby blocking IL-1 induced IRAK degradation ... Importantly, the negative impact of Pellino 3b on IL-1 induced IRAK degradation correlated with the inhibitory effect of Pellino 3b on the IL-1 induced TAK1 dependent pathway, suggesting that a positive role of IRAK degradation in IL-1 induced TAK1 activation
Staschke et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental) : The IL-1R associated kinase 4 (IRAK4) is critical for IL-1/TLR signaling ... The results of these studies demonstrate that IL-1 mediated IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease
Sujita et al., Biochem Biophys Res Commun 1990 : Effect of interleukin 1 (IL-1) on the levels of cytochrome P-450 involving IL-1 receptor on the isolated hepatocytes of rat
Huang et al., J Neurosci 2011 : IL-1 signaling requires the type 1 IL-1 receptor and the IL-1 receptor accessory protein ( IL-1RAcP ) as a receptor partner
Lee et al., Exp Mol Med 2012 (Arthritis, Rheumatoid...) : Adiponectin and IL-1ß each increased the expression of both adiponectin receptor 1 and IL-1 receptor 1
Gallis et al., J Immunol 1989 : IL-1 induces rapid phosphorylation of the IL-1 receptor
Dubois et al., Exp Hematol 1993 : Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells in vivo
Arora et al., J Biol Chem 1995 : These studies therefore demonstrate that activation of intracellular signaling pathways by IL-1 is dependent on IL-1 receptor-cytoskeletal protein interactions
Rédini et al., Arthritis Rheum 1993 : TGF beta reduced both IL-1 effects on matrix metabolism and IL-1 receptor expression
Chandrasekhar et al., Agents Actions Suppl 1993 : To determine whether the two processes are linked, we studied the influence of growth factors on IL-1 induced neutral protease induction, proteoglycan synthesis inhibition and IL-1 receptor expression
Tan et al., J Clin Endocrinol Metab 1996 (Eye Diseases...) : Interleukin-1 (IL-1) receptor antagonist and soluble IL-1 receptor inhibit IL-1 induced glycosaminoglycan production in cultured human orbital fibroblasts from patients with Graves ' ophthalmopathy
Cao et al., Nature 1996 : IL-1 treatment of 293 cells induces the association of TRAF6 with IRAK , a serine/threonine kinase that is rapidly recruited to the IL-1 receptor after IL-1 induction
Chizzolini et al., Eur J Immunol 1997 (Inflammation) : Human Th1 cells preferentially induce interleukin (IL)-1beta while Th2 cells induce IL-1 receptor antagonist production upon cell/cell contact with monocytes
Wesche et al., J Biol Chem 1997 : The interleukin-1 receptor accessory protein ( IL-1RAcP ) is essential for IL-1 induced activation of interleukin-1 receptor associated kinase ( IRAK ) and stress activated protein kinases ( SAP kinases ) ... The expression of IL-1RAcP in EL-4 D6/76 was sufficient to restore IL-1 induced activation of interleukin-1 receptor associated kinase and of stress activated protein kinases, translocation of the transcription factors NFkappaB and IL-1 NF to the nucleus, and induction of IL-2 mRNA synthesis
Ando et al., Endocrinology 1998 : The effects of IL-1 proved relatively specific, contingent upon somatic cell-cell cooperation, dose and time dependent, and IL-1 receptor mediated
Eriksson et al., Int J Mol Med 1998 : Since IL-1 is known to induce expression of both IL-1 and IL-6, we have investigated to what extent the induction of IL-1alpha and IL-6 by betaA25-35, is dependent on the IL-1 receptor type I (IL-1RI) , the only known signalling IL-1 receptor