Gene interactions and pathways from curated databases and text-mining

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IL1A — NPS

Text-mined interactions from Literome

Hulkower et al., Agents Actions 1991 : Although IL-1 induced the NPs and PGE2, it did so without detectable translocation of PKC
Yaraee et al., Iran J Allergy Asthma Immunol 2003 : Each neuropeptide separately has upregulated IL-1 beta production by HSV- 1 infected macrophages with the greatest effect at the concentrations of 1 09M for both SP and CGRP, but no synergistic effect on IL-1 production has been observed in the presence of both neuropeptides at optimal concentrations
Shi et al., Anesth Analg 2011 (Pain) : We then investigated whether these neuropeptides could stimulate production of IL-1ß in a keratinocyte cell line ( REKs ), and could increase the expression of inflammasome component proteins including NALP1 and caspase-1
Segat et al., Nanomedicine (Lond) 2011 : Bare ORMOSIL-NPs effectively stimulated the production of IL-1ß/IL-6/TNF-a/IL-8 by monocytes and of IL-8 by polymorphonuclear leukocytes ( PMNs )
Xue et al., Toxicol Lett 2012 (Inflammation...) : In addition, the secretion levels of TNF-a, IL-1ß and IL-6 were variably increased by all four NPs
Ferin et al., Ann N Y Acad Sci 1993 : In conclusion, we have demonstrated that in the primate increased activity of the immune system and the consequent IL-1 release result in the activation of neuropeptides of the adrenal axis, mainly CRF and AVP